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PXD012851 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleEndo-Lysosomal and Ubiquitin CSF Biomarker Discovery by solid-phase extraction and LC-MS/MS
DescriptionDysfunctional proteostasis is increasingly implicated in neurodegenerative diseases which is exemplified by an accumulation of protein aggregates in the brain in e.g. Alzheimer's and Parkinson's disease. In addition, in Alzheimer's disease there is an accumulation of autophagic vesicles within neurites. Susceptibility in Parkinson's disease has convincingly been connected with genetic mutations associated with lysosomal storage disorders. Proteostasis is maintained in the cell by the endo-lysosomal system, autophagy and the ubiquitin-proteasome system. Identifying biomarkers reflecting proteostasis might increase our understanding of neurodegenerative disorders and serve as tools to monitor the effects of new treatment strategies. To date no treatment has proven effective, neither in Alzheimer’s disease nor Parkinson’s disease. The aim of this project was to identify proteins involved in the endo-lysosomal system, autophagy and the ubiquitin-proteasome system in CSF. This information will be used to select and target relevant proteins for quantitative analysis using e.g. PRM or SRM to evaluate these proteins as potential biomarkers in neurodegenerative diseases.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSimon Sjödin
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-02-25 01:19:03ID requested
12019-09-25 06:37:56announced
Publication List
Sj, ö, din S, Brinkmalm G, Ö, hrfelt A, Parnetti L, Paciotti S, Hansson O, Hardy J, Blennow K, Zetterberg H, Brinkmalm A, Endo-lysosomal proteins and ubiquitin CSF concentrations in Alzheimer's and Parkinson's disease. Alzheimers Res Ther, 11(1):82(2019) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: Human, CSF, SPE, LC-MS/MS
Contact List
Henrik Zetterberg
contact affiliationDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden Department of Molecular Neuroscience, University College London Institute of Neurology, Queen Square, London, UK UK Dementia Research Institute at UCL, London, United Kingdom
contact emailhenrik.zetterberg@clinchem.gu.se
lab head
Simon Sjödin
contact affiliationUniversity of Gothenburg
contact emailsimon.sjodin@neuro.gu.se
dataset submitter
Full Dataset Link List
Dataset FTP location
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