PXD012786

PXD012786 is an original dataset announced via ProteomeXchange.

Title	Synaptosome proteome IGF2 enhancer knockout mice
Description	We identified an enhancer element near IGF2 locus that is possibly involved with dopamine function and schizophrenia. A knockout mouse was generated for the enhancer element in the IGF2 locus. We then characterized the striatal synaptosomes ( i.e. biological fraction representing pre- post synaptic nerve terminal)by mass spectometry from WT and Igf2 enhancer KO mice.
HostingRepository	PRIDE
AnnounceDate	2019-05-31
AnnouncementXML	Submission_2019-05-31_06:04:51.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD012786
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Bryan Killinger
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	Ammonia-loss; iTRAQ4plex; Amidated; GluGlu; Methyl; Hex; Phosphopantetheine; Oxidation; AEC-MAEC; Methylmalonylation; Methylphosphonate; Carboxy; Ethanedithiol; Delta:H(4)C(3); Phospho; Quinone; Cation:Na; Deamidated; Glu; Trp->Oxolactone; Acetyl; Sulfo; cGMP; azole; Nitro; Cation:K; Malonyl; Methyl+Deamidated; Methylthio; GluGluGlu; Formyl; Carbamyl; HexNAc; Carbamidomethyl; Gln->pyro-Glu; trifluoro; Glycerophospho; Glu->pyro-Glu; O-Methylphosphate; GluGluGluGlu; Ammonium; Dehydrated; Biotin; Dioxidation; Hydroxymethyl; Carbofuran
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-02-19 05:23:30	ID requested
⏵ 1	2019-05-31 06:04:52	announced

Pai S, Li P, Killinger B, Marshall L, Jia P, Liao J, Petronis A, Szab, ó PE, Labrie V, Differential methylation of enhancer at IGF2 is associated with abnormal dopamine synthesis in major psychosis. Nat Commun, 10(1):2046(2019) [pubmed]

curator keyword: Biological

submitter keyword: synaptosome, IGF2, schizophrenia, dopamine, striatum

Viviane Labrie
contact affiliation	Department for Neurodegenerative Science Van Andel Institute Grand Rapids, MI
contact email	viviane.labrie@vai.org
lab head
Bryan Killinger
contact affiliation	Van andel institute
contact email	bryan.killinger@vai.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/05/PXD012786

PRIDE project URI

• PRIDE
  1. PXD012786
     1. Label: PRIDE project
     2. Name: Synaptosome proteome IGF2 enhancer knockout mice