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PXD012760

DataSet Summary

  • HostingRepository: PRIDE
  • AnnounceDate: 2019-03-14
  • AnnouncementXML: Submission_2019-03-14_07:49:36.xml
  • DigitalObjectIdentifier:
  • ReviewLevel: Peer-reviewed dataset
  • DatasetOrigin: Original data
  • RepositorySupport: Unsupported dataset by repository
  • PrimarySubmitter: Bianca Klein
  • Title: Carboxylic acid consumption and production by Corynebacterium glutamicum_LC-MS/MS
  • Description: Corynebacterium glutamicum is well-known as an industrial workhorse, most notably for its use in the bulk production of amino acids in the feed and food sector. Fast growth and robustness against oscillatory oxygen availability, which can occur in large-scale bioreactors, are advantageous properties of this bacterium. However, previous studies of the effect of gradients in scale-down reactors with complex media disclosed an accumulation of several carboxylic acids and a parallel decrease of growth and product accumulation by C. glutamicum. This study addresses the impact of carboxylic acids, e.g. acetate and L-lactate, on the cultivation process and their potential role in scale up related performance losses. In order to mimic a discontinuous oxygen supply, a fluctuating power input in shake flask and stirred tank cultivations with mineral salt was applied. One focus of this study is to identify relative changes in the proteome due to the differing availability of carboxylic acids under discontinuous oxygen supply.
  • SpeciesList: scientific name: Corynebacterium glutamicum ATCC 13032; NCBI TaxID: 196627;
  • ModificationList: No PTMs are included in the dataset
  • Instrument: TripleTOF 6600

Dataset History

VersionDatetimeStatusChangeLog Entry
02019-02-18 04:58:34ID requested
12019-03-14 07:49:38announced

Publication List

  1. Conrady M, Lemoine A, Limberg MH, Oldiges M, Neubauer P, Junne S, Carboxylic acid consumption and production by Corynebacterium glutamicum. Biotechnol Prog, 35(3):e2804(2019) [pubmed]

Keyword List

  1. curator keyword: Biological
  2. submitter keyword: carboxylic acid, Corynebacterium glutamicum, scale down, heterogeneity, oxygen oscillation

Contact List

    Marco Oldiges
    • contact affiliation: Institute of Bio- and Geosciences IBG-1: Biotechnology Forschungszentrum Jülich GmbH 52425 Jülich Germany
    • contact email: m.oldiges@fz-juelich.de
    • lab head:
    Bianca Klein
    • contact affiliation: Forschungszentrum Juelich GmbH
    • contact email: b.klein@fz-juelich.de
    • dataset submitter:

Full Dataset Link List

  1. Dataset FTP location
  2. PRIDE project URI
Repository Record List
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