PXD012760

PXD012760 is an original dataset announced via ProteomeXchange.

Title	Carboxylic acid consumption and production by Corynebacterium glutamicum_LC-MS/MS
Description	Corynebacterium glutamicum is well-known as an industrial workhorse, most notably for its use in the bulk production of amino acids in the feed and food sector. Fast growth and robustness against oscillatory oxygen availability, which can occur in large-scale bioreactors, are advantageous properties of this bacterium. However, previous studies of the effect of gradients in scale-down reactors with complex media disclosed an accumulation of several carboxylic acids and a parallel decrease of growth and product accumulation by C. glutamicum. This study addresses the impact of carboxylic acids, e.g. acetate and L-lactate, on the cultivation process and their potential role in scale up related performance losses. In order to mimic a discontinuous oxygen supply, a fluctuating power input in shake flask and stirred tank cultivations with mineral salt was applied. One focus of this study is to identify relative changes in the proteome due to the differing availability of carboxylic acids under discontinuous oxygen supply.
HostingRepository	PRIDE
AnnounceDate	2019-03-14
AnnouncementXML	Submission_2019-03-14_07:49:36.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Bianca Klein
SpeciesList	scientific name: Corynebacterium glutamicum ATCC 13032; NCBI TaxID: 196627;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 6600

Revision	Datetime	Status	ChangeLog Entry
0	2019-02-18 04:58:34	ID requested
⏵ 1	2019-03-14 07:49:38	announced

Conrady M, Lemoine A, Limberg MH, Oldiges M, Neubauer P, Junne S, Carboxylic acid consumption and production by Corynebacterium glutamicum. Biotechnol Prog, 35(3):e2804(2019) [pubmed]

curator keyword: Biological

submitter keyword: carboxylic acid, Corynebacterium glutamicum, scale down, heterogeneity, oxygen oscillation

Marco Oldiges
contact affiliation	Institute of Bio- and Geosciences IBG-1: Biotechnology Forschungszentrum Jülich GmbH 52425 Jülich Germany
contact email	m.oldiges@fz-juelich.de
lab head
Bianca Klein
contact affiliation	Forschungszentrum Juelich GmbH
contact email	b.klein@fz-juelich.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/03/PXD012760

PRIDE project URI

• PRIDE
  1. PXD012760
     1. Label: PRIDE project
     2. Name: Carboxylic acid consumption and production by Corynebacterium glutamicum_LC-MS/MS