PXD012752

PXD012752 is an original dataset announced via ProteomeXchange.

Title	Vipera ammodytes ammodytes venom proteomics
Description	The nose-horned viper, its nominotypical subspecies Vipera ammodytes ammodytes (Vaa) in particular is, medically, the most relevant snake in Europe. The local and systemic clinical manifestations of poisoning by the venom of this snake are the result of the pathophysiological effects inflicted by enzymatic and non-enzymatic venom components acting, most prominently, on blood, cardiovascular and nerve systems. This venom comprises the most complex mixture of pharmacologically active proteins and peptides of all European snakes. To help improve the current antivenom therapy towards higher specificity and efficiency, and to assist drug discovery, we have constructed, by combining transcriptomic and proteomic analyses, the most comprehensive library yet of the Vaa venom proteins and peptides. At the protein level, 57 venom proteins belonging to 16 different protein families have been identified and, with SVSPs, sPLA2s, snaclecs and SVMPs, comprise about 80% of all venom proteins.
HostingRepository	PRIDE
AnnounceDate	2019-05-06
AnnouncementXML	Submission_2019-05-06_10:59:07.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD012752
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Adrijana Leonardi
SpeciesList	scientific name: Vipera ammodytes ammodytes; NCBI TaxID: 8705;
ModificationList	Oxidation; Carbamidomethyl
Instrument	ion trap

Revision	Datetime	Status	ChangeLog Entry
0	2019-02-18 02:54:17	ID requested
⏵ 1	2019-05-06 10:59:09	announced

Leonardi A, Sajevic T, Punger, č, ar J, Kri, ž, aj I, Comprehensive Study of the Proteome and Transcriptome of the Venom of the Most Venomous European Viper: Discovery of a New Subclass of Ancestral Snake Venom Metalloproteinase Precursor-Derived Proteins. J Proteome Res, 18(5):2287-2309(2019) [pubmed]

submitter keyword: snake venom, Vipera ammodytes ammodytes, 2-DE, LC-MS/MS

Igor Križaj
contact affiliation	Department of molecular and biomedical sciences, Jozef Stefan Institute, Slovenia
contact email	igor.krizaj@ijs.si
lab head
Adrijana Leonardi
contact affiliation	Jozef Stefan Institute
contact email	adrijana.leonardi@ijs.si
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/05/PXD012752

PRIDE project URI

• PRIDE
  1. PXD012752
     1. Label: PRIDE project
     2. Name: Vipera ammodytes ammodytes venom proteomics