PXD012742

PXD012742 is an original dataset announced via ProteomeXchange.

Title	Differential responses to stress of two Mycoplasma hyopneumoniae strains
Description	Mycoplasma hyopneumoniae pathogenic strains, like 7448, are the causative agents of porcine enzootic pneumonia. Non-pathogenic strains, like M. hyopneumoniae J, does not cause disease, although shares the entire repertoire of known virulence-related genes with M. hyopneumoniae 7448. In this context, the differential expression of ortholog genes is likely responsible, at least in part, for differences in pathogenicity or virulence level between these strains. Moreover, in the porcine lung, M. hyopneumoniae faces a hostile environment, with both oxidative and heat stresses. The performed comparative proteomics analyses provided evidence of differential stress responses between a pathogenic and a non-pathogenic M. hyopneumoniae strain, involving tens of proteins, including some known virulence factors. The results suggest that stress conditions trigger the expression of potential virulence factors in the pathogenic M. hyopneumoniae 7448, but not in the non-pathogenic M. hyopneumoniae J.
HostingRepository	PRIDE
AnnounceDate	2019-03-29
AnnouncementXML	Submission_2019-03-29_04:14:01.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Henrique Ferreira
SpeciesList	scientific name: Mycoplasma hyopneumoniae 7448; NCBI TaxID: 262722; scientific name: Mycoplasma hyopneumoniae J; NCBI TaxID: 262719;
ModificationList	phosphorylated residue; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2019-02-18 01:21:40	ID requested
⏵ 1	2019-03-29 04:14:02	announced

Paes JA, Leal Zimmer FMA, Moura H, Barr JR, Ferreira HB, Differential responses to stress of two Mycoplasma hyopneumoniae strains. J Proteomics, 199():67-76(2019) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: Mycoplasma hyopneumoniae

oxidative stress

heat stress

LC-MS/MS

virulence

Henrique Bunselmeyer Ferreira
contact affiliation	Laboratório de Genômica Estrutural e Funcional, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
contact email	henrique@cbiot.ufrgs.br
lab head
Henrique Ferreira
contact affiliation	Universidade Federal do Rio Grande do Sul
contact email	henrique@cbiot.ufrgs.br
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/03/PXD012742

PRIDE project URI

• PRIDE
  1. PXD012742
     1. Label: PRIDE project
     2. Name: Differential responses to stress of two Mycoplasma hyopneumoniae strains