PXD012742 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Differential responses to stress of two Mycoplasma hyopneumoniae strains |
Description | Mycoplasma hyopneumoniae pathogenic strains, like 7448, are the causative agents of porcine enzootic pneumonia. Non-pathogenic strains, like M. hyopneumoniae J, does not cause disease, although shares the entire repertoire of known virulence-related genes with M. hyopneumoniae 7448. In this context, the differential expression of ortholog genes is likely responsible, at least in part, for differences in pathogenicity or virulence level between these strains. Moreover, in the porcine lung, M. hyopneumoniae faces a hostile environment, with both oxidative and heat stresses. The performed comparative proteomics analyses provided evidence of differential stress responses between a pathogenic and a non-pathogenic M. hyopneumoniae strain, involving tens of proteins, including some known virulence factors. The results suggest that stress conditions trigger the expression of potential virulence factors in the pathogenic M. hyopneumoniae 7448, but not in the non-pathogenic M. hyopneumoniae J. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:52:58.796.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Henrique Ferreira |
SpeciesList | scientific name: Mycoplasma hyopneumoniae 7448; NCBI TaxID: 262722; scientific name: Mycoplasma hyopneumoniae J; NCBI TaxID: 262719; |
ModificationList | phosphorylated residue; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap Elite |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-02-18 01:21:40 | ID requested | |
1 | 2019-03-29 04:14:02 | announced | |
⏵ 2 | 2024-10-22 04:53:06 | announced | 2024-10-22: Updated project metadata. |
Publication List
Paes JA, Leal Zimmer FMA, Moura H, Barr JR, Ferreira HB, Differential responses to stress of two Mycoplasma hyopneumoniae strains. J Proteomics, 199():67-76(2019) [pubmed] |
10.1016/j.jprot.2019.03.006; |
Keyword List
curator keyword: Biological, Biomedical |
submitter keyword: Mycoplasma hyopneumoniae |
oxidative stress |
heat stress |
LC-MS/MS |
virulence |
Contact List
Henrique Bunselmeyer Ferreira |
contact affiliation | Laboratório de Genômica Estrutural e Funcional, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. |
contact email | henrique@cbiot.ufrgs.br |
lab head | |
Henrique Ferreira |
contact affiliation | Universidade Federal do Rio Grande do Sul |
contact email | henrique@cbiot.ufrgs.br |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD012742
- Label: PRIDE project
- Name: Differential responses to stress of two Mycoplasma hyopneumoniae strains