PXD012720

PXD012720 is an original dataset announced via ProteomeXchange.

Title	Synovial fluid proteome changes in ACL injury-induced posttraumatic osteoarthritis: proteomics analysis of porcine knee synovial fluid
Description	In the current work, we used an isotopically labeled high resolution LC MS/MS-based proteomics approach to analyze the protein profile of synovial fluid at 6 and 12 months after ACL transection in untreated and repaired porcine knees. Our primary aim was to determine how the synovial fluid proteome differs between the two groups in an effort to identify candidate proteins that may be associated with the development of posttraumatic OA. We hypothesized that the development of macroscopic cartilage damage following surgical ACL transection would be accompanied by differential changes in synovial fluid proteome in untreated knees compared to repaired joints.
HostingRepository	PRIDE
AnnounceDate	2019-02-16
AnnouncementXML	Submission_2019-03-05_07:27:19.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ata Kiapour
SpeciesList	scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825;
ModificationList	iTRAQ8plex-116 reporter+balance reagent acylated residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2019-02-15 01:06:35	ID requested
1	2019-02-15 22:22:18	announced
⏵ 2	2019-03-05 07:27:21	announced	Updated publication reference for PubMed record(s): 30822327.

Kiapour AM, Sieker JT, Proffen BL, Lam TT, Fleming BC, Murray MM, Synovial fluid proteome changes in ACL injury-induced posttraumatic osteoarthritis: Proteomics analysis of porcine knee synovial fluid. PLoS One, 14(3):e0212662(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: Porcine, Knee, Synovial Fluide, PTOA, ACL Injury

Ata Kiapour
contact affiliation	Boston Children's Hospital
contact email	ata.kiapour@childrens.harvard.edu
lab head
Ata Kiapour
contact affiliation	Boston Children's Hospital
contact email	ata.kiapour@childrens.harvard.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/02/PXD012720

PRIDE project URI

• PRIDE
  1. PXD012720
     1. Label: PRIDE project
     2. Name: Synovial fluid proteome changes in ACL injury-induced posttraumatic osteoarthritis: proteomics analysis of porcine knee synovial fluid