PXD012713

PXD012713 is an original dataset announced via ProteomeXchange.

Title	Phosphorylation of CPSF6 RS-like domain
Description	Cleavage factor I mammalian (CFIm) complex, composed of cleavage and polyadenylation specificity factor CPSF6, regulates alternative polyadenylation (APA). CPSF6 has a RS-like domain which plays role in protein -protein interactions. This interaction might have role in alternative polyadenylation site selection. The phosphorylation of RS- like domain might play role in protein -protein interaction and thus might have a role in alternative polyadenylation site selection. So we did mass specteroanalysis to analyse phosphorylation sites of RS-like domain of CPSF6.
HostingRepository	PRIDE
AnnounceDate	2019-04-01
AnnouncementXML	Submission_2019-04-01_01:22:10.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Parmit Singh
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2019-02-14 03:43:26	ID requested
⏵ 1	2019-04-01 01:22:12	announced

Jang S, Cook NJ, Pye VE, Bedwell GJ, Dudek AM, Singh PK, Cherepanov P, Engelman AN, Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6. Nucleic Acids Res, 47(9):4663-4683(2019) [pubmed]

submitter keyword: CPSF6, CFIm68, RS domain, RS-like domain, APA

Alan N. Engelman
contact affiliation	Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
contact email	alan_engelman@dfci.harvard.edu
lab head
Parmit Singh
contact affiliation	Dana Farber Cancer Institute, Harvard Medical School
contact email	parmitcrassa@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD012713
     1. Label: PRIDE project
     2. Name: Phosphorylation of CPSF6 RS-like domain