PXD012689 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Sulfisoxazole inhibits exosome secretion for potential breast cancer treatment |
Description | Inhibitors of the secretion of cancer exosomes, which promote cancer progression and metastasis, can not only accelerate exosome biology research but also offer therapeutic benefits for cancer patients. We identified sulfisoxazole (SFX) which inhibits exosome secretion from breast cancer cells. SFX, an FDA-approved oral antibiotic, showed significant anti-tumor and anti-metastatic effects in mouse models of breast cancer xenografts, reduced the expression of proteins involved in exosome biogenesis and secretion, and triggered co-localization of multivesicular endosomes (MVEs) with lysosomes for degradation. These findings provide a foundation for exosome-targeted cancer therapies and the mechanistic studies on exosome biology. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:53:27.489.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Chan-Hyeong Lee |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q-Tof Ultima |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-02-13 03:40:51 | ID requested | |
1 | 2019-11-12 18:50:45 | announced | |
⏵ 2 | 2024-10-22 04:53:35 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
submitter keyword: breast cancer, Sulfisoxazole,exosome, LC-MS/MS |
Contact List
Moon-Chang Baek |
contact affiliation | Department of Molecular Medicine, CMRI, Exosome Convergence Research Center (ECRC), School of Medicine, Kyungpook National University, Daegu, Republic of Korea. |
contact email | mcbaek@knu.ac.kr |
lab head | |
Chan-Hyeong Lee |
contact affiliation | KNU |
contact email | agony0208@naver.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/11/PXD012689 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD012689
- Label: PRIDE project
- Name: Sulfisoxazole inhibits exosome secretion for potential breast cancer treatment