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PXD012689

PXD012689 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSulfisoxazole inhibits exosome secretion for potential breast cancer treatment
DescriptionInhibitors of the secretion of cancer exosomes, which promote cancer progression and metastasis, can not only accelerate exosome biology research but also offer therapeutic benefits for cancer patients. We identified sulfisoxazole (SFX) which inhibits exosome secretion from breast cancer cells. SFX, an FDA-approved oral antibiotic, showed significant anti-tumor and anti-metastatic effects in mouse models of breast cancer xenografts, reduced the expression of proteins involved in exosome biogenesis and secretion, and triggered co-localization of multivesicular endosomes (MVEs) with lysosomes for degradation. These findings provide a foundation for exosome-targeted cancer therapies and the mechanistic studies on exosome biology.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:53:27.489.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterChan-Hyeong Lee
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ-Tof Ultima
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-02-13 03:40:51ID requested
12019-11-12 18:50:45announced
22024-10-22 04:53:35announced2024-10-22: Updated project metadata.
Publication List
10.1038/s41467-019-09387-4;
Keyword List
submitter keyword: breast cancer, Sulfisoxazole,exosome, LC-MS/MS
Contact List
Moon-Chang Baek
contact affiliationDepartment of Molecular Medicine, CMRI, Exosome Convergence Research Center (ECRC), School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
contact emailmcbaek@knu.ac.kr
lab head
Chan-Hyeong Lee
contact affiliationKNU
contact emailagony0208@naver.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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