PXD012688

PXD012688 is an original dataset announced via ProteomeXchange.

Title	Human Salivary Neutrophil Defensins (Alpha-Defensins)
Description	In the HPLC high-resolution ESI-MS profiles of both Predominantly Antibody Deficiency syndromes subjects and healthy controls saliva samples, four proteins, with exp. monoisotopic ion [M+H]+ at 3440.54 ± 0.06 m/z, 3369.50± 0.06 m/z, 3484.51 ± 0.06 m/z and 3707.77 ± 0.06, eluting between 24.5-26.6 minutes, were detected. The monoisotopic mass values and the manual inspection of the high-resolution MS/MS spectra of the ions at [M+5H]+5 at 689.31, 675.10, 698.11 and 742.76 m/z, and of the ions at [M+4H]+4 at 843.63, 872.39 m/z allowed to establish that the four proteins were alpha defensins 1, 2, 3 and 4.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:50:09.362.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Barbara Manconi
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2019-02-13 03:40:10	ID requested
1	2020-01-09 10:53:17	announced
2	2020-01-10 00:19:28	announced	2020-01-10: Updated publication reference for DOI(s): 10.1007/s10875-020-00743-4.
3	2020-01-17 06:29:14	announced	2020-01-10: Updated publication reference for DOI(s): 10.1007/s10875-020-00743-4. 2020-01-17: Updated publication reference for PubMed record(s): 31916122. 2020-01-17: Updated publication reference for DOI(s): 10.1007/s10875-020-00743-4.
⏵ 4	2023-11-14 08:50:15	announced	2023-11-14: Updated project metadata.

Contini C, Firinu D, Serrao S, Manconi B, Olianas A, Cinetto F, Cossu F, Castagnola M, Messana I, Del Giacco S, Cabras T, RP-HPLC-ESI-IT Mass Spectrometry Reveals Significant Variations of the Human Salivary Protein Profile Associated with Predominantly Antibody Deficiencies. J Clin Immunol, 40(2):329-339(2020) [pubmed]

submitter keyword: saliva, high resolution mass spectrometry, Top-Down proteomics,human alpha defensins

Barbara Manconi
contact affiliation	University of Cagliari, Dip. Scienze della Vita e dell'Ambiente Macrosezione Biomedica - laboratorio di Biochimica
contact email	bmanconi@unica.it
lab head
Barbara Manconi
contact affiliation	University of Cagliari
contact email	bmanconi@unica.it
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/01/PXD012688

PRIDE project URI

• PRIDE
  1. PXD012688
     1. Label: PRIDE project
     2. Name: Human Salivary Neutrophil Defensins (Alpha-Defensins)