PXD012679

PXD012679 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Global Proteomic Analysis of E-cadherin Function in Mouse Embryonic Stem Cells Using iTRAQ and LC-MS/MS
Description	This project identifies all the proteomic changes that take place in mouse embryonic stem cells after the knockout of the cell-cell adhesion protein E-cadherin. It identifies several putative pathways and sheds the light on the role of E-cadherin in controlling metabolsim of these pluripotent stem cells. The downregulation of E-cadherin resulted in the inhibiton of mitochondrial complex III and the upregulation of HIF-alpha-1 targets
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:08:41.269.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Aseel Sharaireh
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iTRAQ8plex-116 reporter+balance reagent acylated residue
Instrument	QSTAR

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2019-02-12 07:31:50	ID requested
1	2020-07-09 02:14:42	announced
⏵ 2	2024-10-22 05:08:43	announced	2024-10-22: Updated project metadata.

Publication List

10.1002/stem.3249;
Sharaireh AM, Fitzpatrick LM, Ward CM, McKay TR, Unwin RD, ve and primed pluripotent states in mouse embryonic stem cells. Stem Cells, 38(10):1292-1306(2020) [pubmed]

10.1002/stem.3249;

Sharaireh AM, Fitzpatrick LM, Ward CM, McKay TR, Unwin RD, ve and primed pluripotent states in mouse embryonic stem cells. Stem Cells, 38(10):1292-1306(2020) [pubmed]

Keyword List

submitter keyword: Metabolism,mESCs, E-cadherin, iTRAQ, LC-MS/MS

submitter keyword: Metabolism,mESCs, E-cadherin, iTRAQ, LC-MS/MS

Contact List

Dr Richard Unwin
contact affiliation	Division of Cardiovascular Sciences-School of Medical Sciences- University of Manchester
contact email	r.unwin@manchester.ac.uk
lab head
Aseel Sharaireh
contact affiliation	PhD Student
contact email	aseel.sharaireh@manchester.ac.uk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/07/PXD012679
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/07/PXD012679

PRIDE project URI

Repository Record List

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