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PXD012679

PXD012679 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleGlobal Proteomic Analysis of E-cadherin Function in Mouse Embryonic Stem Cells Using iTRAQ and LC-MS/MS
DescriptionThis project identifies all the proteomic changes that take place in mouse embryonic stem cells after the knockout of the cell-cell adhesion protein E-cadherin. It identifies several putative pathways and sheds the light on the role of E-cadherin in controlling metabolsim of these pluripotent stem cells. The downregulation of E-cadherin resulted in the inhibiton of mitochondrial complex III and the upregulation of HIF-alpha-1 targets
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:08:41.269.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAseel Sharaireh
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListiTRAQ8plex-116 reporter+balance reagent acylated residue
InstrumentQSTAR
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-02-12 07:31:50ID requested
12020-07-09 02:14:42announced
22024-10-22 05:08:43announced2024-10-22: Updated project metadata.
Publication List
10.1002/stem.3249;
Sharaireh AM, Fitzpatrick LM, Ward CM, McKay TR, Unwin RD, ve and primed pluripotent states in mouse embryonic stem cells. Stem Cells, 38(10):1292-1306(2020) [pubmed]
Keyword List
submitter keyword: Metabolism,mESCs, E-cadherin, iTRAQ, LC-MS/MS
Contact List
Dr Richard Unwin
contact affiliationDivision of Cardiovascular Sciences-School of Medical Sciences- University of Manchester
contact emailr.unwin@manchester.ac.uk
lab head
Aseel Sharaireh
contact affiliationPhD Student
contact emailaseel.sharaireh@manchester.ac.uk
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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