PXD012679 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Global Proteomic Analysis of E-cadherin Function in Mouse Embryonic Stem Cells Using iTRAQ and LC-MS/MS |
Description | This project identifies all the proteomic changes that take place in mouse embryonic stem cells after the knockout of the cell-cell adhesion protein E-cadherin. It identifies several putative pathways and sheds the light on the role of E-cadherin in controlling metabolsim of these pluripotent stem cells. The downregulation of E-cadherin resulted in the inhibiton of mitochondrial complex III and the upregulation of HIF-alpha-1 targets |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:08:41.269.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Aseel Sharaireh |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | iTRAQ8plex-116 reporter+balance reagent acylated residue |
Instrument | QSTAR |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-02-12 07:31:50 | ID requested | |
1 | 2020-07-09 02:14:42 | announced | |
⏵ 2 | 2024-10-22 05:08:43 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1002/stem.3249; |
Sharaireh AM, Fitzpatrick LM, Ward CM, McKay TR, Unwin RD, ve and primed pluripotent states in mouse embryonic stem cells. Stem Cells, 38(10):1292-1306(2020) [pubmed] |
Keyword List
submitter keyword: Metabolism,mESCs, E-cadherin, iTRAQ, LC-MS/MS |
Contact List
Dr Richard Unwin |
contact affiliation | Division of Cardiovascular Sciences-School of Medical Sciences- University of Manchester |
contact email | r.unwin@manchester.ac.uk |
lab head | |
Aseel Sharaireh |
contact affiliation | PhD Student |
contact email | aseel.sharaireh@manchester.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/07/PXD012679 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD012679
- Label: PRIDE project
- Name: Global Proteomic Analysis of E-cadherin Function in Mouse Embryonic Stem Cells Using iTRAQ and LC-MS/MS