PXD012667

PXD012667 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Oxidative Stress Biomarker of Type 2 Diabetes Mellitus
Description	In this project, using discovery-based mass spectrometry approach and adopting data-dependent LC-MS/MS, we detected and identified modified peptides in complex clinical plasma samples and developed first-level biomarker verification strategy. Further, using liquid chromatography-multiple reaction monitoring mass spectrometry (LC-MRM-MS) based targeted approach which virtually quantifies irreversible oxidation at any targeted cysteine, we quantified cysteine tri-oxidation in HSA in diabetes patients. Site-specific tri-oxidized HSA could be a potential biomarker of diabetes and provide directive of disease mechanism.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:05:07.624.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sunil Adav
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2019-02-12 01:56:07	ID requested
1	2020-05-26 13:20:30	announced
⏵ 2	2024-10-22 05:05:15	announced	2024-10-22: Updated project metadata.

Publication List

10.1038/s41598-020-62341-z;
Paramasivan S, Adav SS, Ngan SC, Dalan R, Leow MK, Ho HH, Sze SK, Serum albumin cysteine trioxidation is a potential oxidative stress biomarker of type 2 diabetes mellitus. Sci Rep, 10(1):6475(2020) [pubmed]

10.1038/s41598-020-62341-z;

Paramasivan S, Adav SS, Ngan SC, Dalan R, Leow MK, Ho HH, Sze SK, Serum albumin cysteine trioxidation is a potential oxidative stress biomarker of type 2 diabetes mellitus. Sci Rep, 10(1):6475(2020) [pubmed]

Keyword List

curator keyword: Biomedical
submitter keyword: Human Plasma

curator keyword: Biomedical

submitter keyword: Human Plasma

Contact List

Prof Sze S K
contact affiliation	Nanyang Technological University
contact email	sksze@ntu.edu.sg
lab head
Sunil Adav
contact affiliation	Nanyang Technological University
contact email	ssadav@ntu.edu.sg
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/05/PXD012667
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/05/PXD012667

PRIDE project URI

Repository Record List

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