PXD012665 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Deciphering functions of VHL in Clear Cell Renal Cell Carcinoma |
Description | VHL is the most frequently mutated gene in ccRCC.It functions via the oxygen-dependent ubiquitin-mediated degradation of hypoxia-inducible factor (HIF). The stabilization and hyperactivation of HIF1 play essential roles in tumorigenesis. This is a TMT based proteomics experiment aimed to investigate the functions of VHL in ccRCC systematically. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:26:11.330.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Songbiao Zhu |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-02-12 01:55:24 | ID requested | |
1 | 2023-01-05 02:49:04 | announced | |
⏵ 2 | 2023-11-14 08:26:12 | announced | 2023-11-14: Updated project metadata. |
Publication List
Zhu S, Ding W, Chen Y, Wang W, Xu R, Liu C, Liu X, Deng H, High VHL Expression Reverses Warburg Phenotype and Enhances Immunogenicity in Kidney Tumor Cells. Genomics Proteomics Bioinformatics, 20(4):657-669(2022) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: renal cancer |
VHL |
immunogenicity |
proteostasis |
Contact List
Haiteng Deng |
contact affiliation | MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systematic Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China |
contact email | dht@tsinghua.edu.cn |
lab head | |
Songbiao Zhu |
contact affiliation | Tsinghua University |
contact email | songbiao_zhu@163.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/01/PXD012665 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD012665
- Label: PRIDE project
- Name: Deciphering functions of VHL in Clear Cell Renal Cell Carcinoma