PXD012612
PXD012612 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | The HSP40 chaperone Ydj1/DnaJA1 drives amyloid beta toxicity |
Description | Amyloid beta 42 (Abeta42) is the principal trigger of neurodegeneration during Alzheimer’s disease (AD); however, the etiology of Abeta42 toxicity remains elusive. In a proteomic approach using a yeast model for intracellular Abeta42 toxicity, we here identify the HSP40 family member Ydj1, the yeast orthologue of human DnaJA1, as a crucial factor in Abeta42-mediated toxicity. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:35:56.486.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Joern Dengjel |
SpeciesList | scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932; |
ModificationList | No PTMs are included in the dataset |
Instrument | LTQ Orbitrap |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2019-02-07 03:54:05 | ID requested | |
1 | 2022-04-26 16:27:56 | announced | |
⏵ 2 | 2024-10-22 05:35:57 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.15252/emmm.202113952; |
Ring J, Tadic J, Ristic S, Poglitsch M, Bergmann M, Radic N, Mossmann D, Liang Y, Maglione M, Jerkovic A, Hajiraissi R, Hanke M, K, ü, ttner V, Wolinski H, Zimmermann A, Domuz Trifunovi, ć L, Mikolasch L, Moretti DN, Broeskamp F, Westermayer J, Abraham C, Schauer S, Dammbrueck C, Hofer SJ, Abdellatif M, Grundmeier G, Kroemer G, Braun RJ, Hansen N, Sommer C, Ninkovic M, Seba S, Rockenfeller P, V, ö, gtle FN, Dengjel J, Meisinger C, Keller A, Sigrist SJ, Eisenberg T, Madeo F, The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity. EMBO Mol Med, 14(5):e13952(2022) [pubmed] |
Keyword List
curator keyword: Biological, Biomedical |
submitter keyword: LC-MS/MS, Alzheimer’s disease, yeast, Saccharomyces cerevisiae, SILAC |
Contact List
Joern Dengjel | |
---|---|
contact affiliation | Dr. Jörn Dengjel Department of Biology, University of Fribourg Chemin du Musée 10, 1700 Fribourg, Switzerland T +41 26 300 8631 E joern.dengjel@unifr.ch |
contact email | joern.dengjel@unifr.ch |
lab head | |
Joern Dengjel | |
contact affiliation | University of Fribourg |
contact email | joern.dengjel@medizin.uni-freiburg.de |
dataset submitter |
Full Dataset Link List
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD012612 |
PRIDE project URI |
Repository Record List
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