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PXD012612

PXD012612 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe HSP40 chaperone Ydj1/DnaJA1 drives amyloid beta toxicity
DescriptionAmyloid beta 42 (Abeta42) is the principal trigger of neurodegeneration during Alzheimer’s disease (AD); however, the etiology of Abeta42 toxicity remains elusive. In a proteomic approach using a yeast model for intracellular Abeta42 toxicity, we here identify the HSP40 family member Ydj1, the yeast orthologue of human DnaJA1, as a crucial factor in Abeta42-mediated toxicity.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:35:56.486.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJoern Dengjel
SpeciesList scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932;
ModificationListNo PTMs are included in the dataset
InstrumentLTQ Orbitrap
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-02-07 03:54:05ID requested
12022-04-26 16:27:56announced
22024-10-22 05:35:57announced2024-10-22: Updated project metadata.
Publication List
10.15252/emmm.202113952;
Ring J, Tadic J, Ristic S, Poglitsch M, Bergmann M, Radic N, Mossmann D, Liang Y, Maglione M, Jerkovic A, Hajiraissi R, Hanke M, K, ü, ttner V, Wolinski H, Zimmermann A, Domuz Trifunovi, ć L, Mikolasch L, Moretti DN, Broeskamp F, Westermayer J, Abraham C, Schauer S, Dammbrueck C, Hofer SJ, Abdellatif M, Grundmeier G, Kroemer G, Braun RJ, Hansen N, Sommer C, Ninkovic M, Seba S, Rockenfeller P, V, ö, gtle FN, Dengjel J, Meisinger C, Keller A, Sigrist SJ, Eisenberg T, Madeo F, The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity. EMBO Mol Med, 14(5):e13952(2022) [pubmed]
Keyword List
curator keyword: Biological, Biomedical
submitter keyword: LC-MS/MS, Alzheimer’s disease, yeast, Saccharomyces cerevisiae, SILAC
Contact List
Joern Dengjel
contact affiliationDr. Jörn Dengjel Department of Biology, University of Fribourg Chemin du Musée 10, 1700 Fribourg, Switzerland T +41 26 300 8631 E joern.dengjel@unifr.ch
contact emailjoern.dengjel@unifr.ch
lab head
Joern Dengjel
contact affiliationUniversity of Fribourg
contact emailjoern.dengjel@medizin.uni-freiburg.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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