PXD012612

PXD012612 is an original dataset announced via ProteomeXchange.

Title	The HSP40 chaperone Ydj1/DnaJA1 drives amyloid beta toxicity
Description	Amyloid beta 42 (Abeta42) is the principal trigger of neurodegeneration during Alzheimer’s disease (AD); however, the etiology of Abeta42 toxicity remains elusive. In a proteomic approach using a yeast model for intracellular Abeta42 toxicity, we here identify the HSP40 family member Ydj1, the yeast orthologue of human DnaJA1, as a crucial factor in Abeta42-mediated toxicity.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:35:56.486.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Joern Dengjel
SpeciesList	scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2019-02-07 03:54:05	ID requested
1	2022-04-26 16:27:56	announced
⏵ 2	2024-10-22 05:35:57	announced	2024-10-22: Updated project metadata.

10.15252/emmm.202113952;

Ring J, Tadic J, Ristic S, Poglitsch M, Bergmann M, Radic N, Mossmann D, Liang Y, Maglione M, Jerkovic A, Hajiraissi R, Hanke M, K, ü, ttner V, Wolinski H, Zimmermann A, Domuz Trifunovi, ć L, Mikolasch L, Moretti DN, Broeskamp F, Westermayer J, Abraham C, Schauer S, Dammbrueck C, Hofer SJ, Abdellatif M, Grundmeier G, Kroemer G, Braun RJ, Hansen N, Sommer C, Ninkovic M, Seba S, Rockenfeller P, V, ö, gtle FN, Dengjel J, Meisinger C, Keller A, Sigrist SJ, Eisenberg T, Madeo F, The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity. EMBO Mol Med, 14(5):e13952(2022) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: LC-MS/MS, Alzheimer’s disease, yeast, Saccharomyces cerevisiae, SILAC

Joern Dengjel
contact affiliation	Dr. Jörn Dengjel Department of Biology, University of Fribourg Chemin du Musée 10, 1700 Fribourg, Switzerland T +41 26 300 8631 E joern.dengjel@unifr.ch
contact email	joern.dengjel@unifr.ch
lab head
Joern Dengjel
contact affiliation	University of Fribourg
contact email	joern.dengjel@medizin.uni-freiburg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD012612

PRIDE project URI

• PRIDE
  1. PXD012612
     1. Label: PRIDE project
     2. Name: The HSP40 chaperone Ydj1/DnaJA1 drives amyloid beta toxicity