PXD012566

PXD012566 is an original dataset announced via ProteomeXchange.

Title	A mass spectrometry guided pre-clinical funnel for the identification of novel vaccine candidates against Helicobacter pylori
Description	We established a generic pipeline for the identification of surface-exposed vaccine candidates in gram-negative bacteria. Using Helicobacter pylori as a model organism, our approach combines design of experiment driven surface shaving with quantitative mass spectrometry to identify 22 highly conserved vaccine candidates, some of which we exemplarily validate.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:52:40.615.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mario Oroshi
SpeciesList	scientific name: Helicobacter pylori J99 (Campylobacter pylori J99); NCBI TaxID: 85963;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2019-01-30 08:09:22	ID requested
1	2019-11-11 01:31:05	announced
2	2019-11-27 01:42:24	announced	2019-11-27: Updated publication reference for PubMed record(s): 31758014.
⏵ 3	2024-10-22 04:52:48	announced	2024-10-22: Updated project metadata.

Hornburg D, Kruse T, Anderl F, Daschkin C, Semper RP, Klar K, Guenther A, Mej, í, as-Luque R, Schneiderhan-Marra N, Mann M, Meissner F, Gerhard M, A mass spectrometry guided approach for the identification of novel vaccine candidates in gram-negative pathogens. Sci Rep, 9(1):17401(2019) [pubmed]

10.1038/s41598-019-53493-8;

curator keyword: Biomedical

submitter keyword: Proteomics, vaccine, surfome, Helicobacter pylori

Felix Meissner
contact affiliation	Experimental Systems Immunology, Max Planck Institute of Biochemistry, Martinsried, Germany
contact email	meissner@biochem.mpg.de
lab head
Mario Oroshi
contact affiliation	Proteomics
contact email	oroshi@biochem.mpg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/11/PXD012566

PRIDE project URI

• PRIDE
  1. PXD012566
     1. Label: PRIDE project
     2. Name: A mass spectrometry guided pre-clinical funnel for the identification of novel vaccine candidates against Helicobacter pylori