PXD012459

PXD012459 is an original dataset announced via ProteomeXchange.

Title	Carbo-loading in fungal lung pathogens: a quantitative analysis of CAZyme abundance and resulting glycan populations
Description	Herein we i) identify Coccidioides spp.-specific CAZymes by bioinformatically comparing the CAZyme repertoire (CAZome) of Coccidioides spp. to other common fungal lung pathogens and a non-pathogenic close fungal relative, ii) experimentally evaluate Coccidioides spp. CAZyme abundance in vivo and in vitro, and iii) identify Coccidioides genus-specific N-glycans by experimentally determining the N-glycan population (N-glycome) of Coccidioides-infected lung tissues using tandem mass spectrometry. As far as we are aware, this is the first use of mass spectrometry to compare the N-glycomes and CAZomes of different fungal genera during infection in human hosts.
HostingRepository	PRIDE
AnnounceDate	2019-11-11
AnnouncementXML	Submission_2019-11-11_03:02:36.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Natalie Mitchell
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	deamidated residue
Instrument	LTQ Orbitrap Velos; Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-01-22 03:07:44	ID requested
⏵ 1	2019-11-11 03:02:37	announced

Mitchell NM, Grys TE, Lake DF, Carbo-loading in Coccidioides spp.: A quantitative analysis of CAZyme abundance and resulting glycan populations. Glycobiology, 30(3):186-197(2020) [pubmed]

curator keyword: Biomedical

submitter keyword: Coccidioides, CAZymes, glycans, glycomics, proteomics, Valley Fever

DOUGLAS LAKE
contact affiliation	PI/ PROFESSOR
contact email	DOUGLAS.LAKE@ASU.EDU
lab head
Natalie Mitchell
contact affiliation	PhD Student
contact email	nmitche3@asu.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/11/PXD012459

PRIDE project URI

• PRIDE
  1. PXD012459
     1. Label: PRIDE project
     2. Name: Carbo-loading in fungal lung pathogens: a quantitative analysis of CAZyme abundance and resulting glycan populations