PXD012453

PXD012453 is an original dataset announced via ProteomeXchange.

Title	Integrated analysis of label-free quantitative proteomics and bioinformatics reveal insights into signaling pathways in male breast cancer
Description	The project contains raw and result files from a proteomic profiling of a male breast cancer (MBC) case. Label-free quantification-mass spectrometry (LFQ-MS) and bioinformatics analysis were employed to investigate the differentially expressed proteins (DEPs) among distinct tissue samples: the primary breast tumor, axillary metastatic lymph nodes and the adjacent non-tumor breast tissue. An additional proteomic comparative analysis was performed with a primary breast tumor of a female patient. A number of Ingenuity® Pathway Analysis (IPA) (QIAGEN Inc.) and functional annotation tools were used to further analyze the DEPs. Altogether, our findings revealed deregulated proteins into signaling pathways involved in the cancer development and provided a landscape of proteomic data for the MBC research.
HostingRepository	PRIDE
AnnounceDate	2021-09-08
AnnouncementXML	Submission_2021-09-08_09:24:28.782.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Michel Batista
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	LTQ Orbitrap XL ETD

Revision	Datetime	Status	ChangeLog Entry
0	2019-01-21 06:45:39	ID requested
⏵ 1	2021-09-08 09:24:29	announced

Gomig THB, Gontarski AM, Cavalli IJ, Souza RLR, Lucena ACR, Batista M, Machado KC, Marchini FK, Marchi FA, Lima RS, Urban CA, Marchi RD, Cavalli LR, Ribeiro EMSF, Integrated analysis of label-free quantitative proteomics and bioinformatics reveal insights into signaling pathways in male breast cancer. Genet Mol Biol, 44(1):e20190410(2021) [pubmed]

curator keyword: Biomedical

submitter keyword: Male breast cancer, signaling pathways, proteomics, label-free mass spectrometry, bioinformatics analysis

Enilze Maria de Souza Fonseca Ribeiro
contact affiliation	Genetics Department, Federal University of Parana, Curitiba, Brazil
contact email	enilzeribeiro@gmail.com
lab head
Michel Batista
contact affiliation	Fiocruz
contact email	batista.mic@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD012453

PRIDE project URI

• PRIDE
  1. PXD012453
     1. Label: PRIDE project
     2. Name: Integrated analysis of label-free quantitative proteomics and bioinformatics reveal insights into signaling pathways in male breast cancer