<<< Full experiment listing


PXD012341 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleImproving Mass Spectrometry Analysis of Protein Structures with Arginine-Selective Chemical Cross-linkers
Descriptionwe develop a series of arginine selective bifunctional aromatic glyoxal cross-linkers (ArGOs) and demonstrate their ability to cross-link model proteins and a protein complex. We also introduce the first arginine-lysine heterobifunctional cross-linker (KArGO), which provides significantly greater surface coverage than the corresponding homobifunctional reagents (e.g. ArGOs and BS3), due to access to the combined abundances of lysine and arginine residues.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYong Cao
SpeciesList scientific name: Escherichia coli; NCBI TaxID: 562;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-01-14 23:42:24ID requested
12019-01-14 23:43:41announced
22019-12-10 22:30:49announced2019-12-11: Update publication information.
Publication List
Jones AX, Cao Y, Tang YL, Wang JH, Ding YH, Tan H, Chen ZL, Fang RQ, Yin J, Chen RC, Zhu X, She Y, Huang N, Shao F, Ye K, Sun RX, He SM, Lei X, Dong MQ, Improving mass spectrometry analysis of protein structures with arginine-selective chemical cross-linkers. Nat Commun, 10(1):3911(2019) [pubmed]
Keyword List
submitter keyword: LC-MS/MS, CXMS, Arginine-Selective Cross-linkers
Contact List
Meng-Qiu Dong
contact affiliationNational Institute of Biological Sciences, Beijing
contact emaildongmengqiu@nibs.ac.cn
lab head
Yong Cao
contact affiliationNational Institute of Biological Sciences, Beijing
contact emailcaoyong@nibs.ac.cn
dataset submitter
Full Dataset Link List
iProX dataset URI