PXD012288

PXD012288 is an original dataset announced via ProteomeXchange.

Title	786-O LC-MS/MS
Description	BRCA1-associated protein 1 (BAP1) is a member of the ubiquitin C‑terminal hydrolase family of deubiquitinating enzymes and is implicated in transcriptional regulation. The BAP1 gene is mutated in about 10% of patients with clear cell renal cell carcinoma (ccRCC), the most common form of renal cancer, suggesting that BAP1 may be a tumor suppressor. However, whether BAP1 influences the progression of ccRCC tumors expressing WT BAP1 is unclear. Here, we assessed the expression and function of BAP1 using human ccRCC specimens and cell lines.
HostingRepository	PRIDE
AnnounceDate	2019-04-18
AnnouncementXML	Submission_2019-04-18_02:13:45.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Pengsheng Chen
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2019-01-09 05:32:18	ID requested
⏵ 1	2019-04-18 02:13:46	announced

Chen P, Wang H, Zhang W, Chen Y, Lv Y, Wu D, Guo M, Deng H, Loss of BAP1 Results in Growth Inhibition and Enhances Mesenchymal-Epithelial Transition in Kidney Tumor Cells. Mol Cell Proteomics, 18(7):1320-1329(2019) [pubmed]

curator keyword: Biological

submitter keyword: 786-O BAP1 LC-MS/MS

Haiteng Deng
contact affiliation	School of Life Science, Tsinghua University, China
contact email	dht@mail.tsinghua.edu.cn
lab head
Pengsheng Chen
contact affiliation	Tsinghua Univ
contact email	878357025@qq.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/04/PXD012288

PRIDE project URI

• PRIDE
  1. PXD012288
     1. Label: PRIDE project
     2. Name: 786-O LC-MS/MS