PXD012284

PXD012284 is an original dataset announced via ProteomeXchange.

Title	Common and distinct pathophysiological processes associated to ileal and colonic ulcers in Crohn’s disease
Description	Based on genetic risk factors and natural history, Crohn’s disease (CD) can be separated in two entities, an ileal and a colonic disease. Protein based-approaches are needed to elucidate whether such subphenotypes are related to distinct pathophysiological processes. In this work, we compared the proteome of ulcer edge to the one of paired control tissue in ileum and colon of CD patients. We revealed that ileal and colonic ulcer edge can be distinguished by a differential distribution of epithelial–mesenchymal transition proteins, neutrophil degranulation proteins and ribosomal proteins. In ileal and colonic ulcer edge, we found a quasi-systematic increase of the proteins implicated in the pathway of protein processing in endoplasmic reticulum and a quasi-systematic decrease of mitochondrial proteins. Our study provides for the first time protein-based evidences showing partly distinct pathophysiological processes associated to ileal and colonic ulcer edge in CD. This could constitute a first step toward the development of gut segment-specific diagnostic markers and therapeutics.
HostingRepository	PRIDE
AnnounceDate	2019-07-15
AnnouncementXML	Submission_2019-07-15_03:26:58.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	nicolas Pierre
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-01-09 02:42:57	ID requested
⏵ 1	2019-07-15 03:26:59	announced

Pierre N, Sal, é, e C, Massot C, Bl, é, tard N, Mazzucchelli G, Smargiasso N, Morsa D, Baiwir D, De Pauw E, Reenaers C, Van Kemseke C, Loly JP, Delvenne P, Meuwis MA, Louis E, Proteomics Highlights Common and Distinct Pathophysiological Processes Associated with Ileal and Colonic Ulcers in Crohn's Disease. J Crohns Colitis, 14(2):205-215(2020) [pubmed]

curator keyword: Biomedical

submitter keyword: Crohn’s disease, ileum, colon, ulcer, proteomics

Edouard Louis
contact affiliation	Laboratory of Translational Gastroenterology, GIGA-institute, University of Liège, 4000 Liège, Belgium Hepato-Gastroenterology and Digestive Oncology Department, Liège University Hospital CHU, 4000 Liège, Belgium
contact email	Edouard.Louis@uliege.be
lab head
nicolas Pierre
contact affiliation	GIGA-R - Translational Gastroenterology, Liège University
contact email	nicolas.pierre@uliege.be
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/07/PXD012284

PRIDE project URI

• PRIDE
  1. PXD012284
     1. Label: PRIDE project
     2. Name: Common and distinct pathophysiological processes associated to ileal and colonic ulcers in Crohn’s disease