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PXD012277

PXD012277 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteome of HEK293T cells upon P2YR6 overexpression
DescriptionDefense against virus infections relies on rapid and massive engagement of cellular proteins with antiviral properties. Germline-encoded pattern recognition receptors (PRRs) sense the presence of pathogens and initiate a signaling cascade leading to the induction of antiviral cytokines, including type-I interferons. IFN-alpha/beta bind to the IFN receptor (IFNAR), initiating signaling that culminates in the expression of interferon-stimulated genes (ISGs). In sum, viral infection triggers the expression of several hundred proteins covering a wide range of biological activities. Among these proteins are PRRs (e.g. RIG-I, MDA5, TLRs), signaling molecules (e.g. MYD88, MAVS), transcription factors (e.g. IRFs, STATs) and proteins with direct antiviral functions (e.g. MX proteins, IFITs), as well as negative regulators of immune responses (e.g. SOCS proteins, DAPK1) that prevent overshooting of immune reactions. ISGs are thus a heterogeneous group of proteins that serve different purposes related to direct antiviral defense and immune regulation.
HostingRepositoryPRIDE
AnnounceDate2019-03-01
AnnouncementXMLSubmission_2019-04-03_06:43:06.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterPietro Scaturro
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-01-09 01:50:28ID requested
12019-03-01 10:12:32announced
22019-04-03 06:43:07announcedUpdated publication reference for PubMed record(s): 30833792.
Publication List
Hubel P, Urban C, Bergant V, Schneider WM, Knauer B, Stukalov A, Scaturro P, Mann A, Brunotte L, Hoffmann HH, Schoggins JW, Schwemmle M, Mann M, Rice CM, Pichlmair A, A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. Nat Immunol, 20(4):493-502(2019) [pubmed]
Keyword List
curator keyword: Biological, Biomedical
submitter keyword: P2YR6, LFQ, QExactive, Label-free quantification
Contact List
Andreas Pichlmair
contact affiliationInstitute of Virology - Viral Immunopathology, Faculty of Medicine, Technical University Munich
contact emailandreas.pichlmair@tum.de
lab head
Pietro Scaturro
contact affiliationTechnical University Munich, Department of Virology
contact emailpietro.scaturro@tum.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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