PXD012275

PXD012275 is an original dataset announced via ProteomeXchange.

Title	FluAV vRNP interactome
Description	Interferon-stimulated genes (ISGs) form the backbone of innate immune system and are pivotal for limiting intra- and intercellular viral replication and spread. We conducted a mass spectrometry–based survey to understand the fundamental organization of the innate immune system and to explore molecular functions of individual ISGs. We identified interactions between 104 ISGs and 1,401 cellular binding partners engaging in 2,734 high-confidence interactions. 90% of these interactions are unreported so far, and our survey therefore illuminates a far wider activity spectrum of ISGs than currently known. Integration of the resulting ISG-interaction network with published datasets and functional studies allowed us to identify novel regulators of immunity and immune system–related processes. Given the extraordinary robustness of the innate immune system, this ISG network may serve as a blueprint for therapeutic targeting of cellular systems in order to efficiently fight viral infections.
HostingRepository	PRIDE
AnnounceDate	2019-03-01
AnnouncementXML	Submission_2019-04-03_06:42:20.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Pietro Scaturro
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2019-01-09 01:49:59	ID requested
1	2019-03-01 08:44:46	announced
⏵ 2	2019-04-03 06:42:21	announced	Updated publication reference for PubMed record(s): 30833792.

Hubel P, Urban C, Bergant V, Schneider WM, Knauer B, Stukalov A, Scaturro P, Mann A, Brunotte L, Hoffmann HH, Schoggins JW, Schwemmle M, Mann M, Rice CM, Pichlmair A, A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. Nat Immunol, 20(4):493-502(2019) [pubmed]

curator keyword: Biological

submitter keyword: FluAV, RNPs, AP-LC-MS/MS, Influenza

Andreas Pichlmair
contact affiliation	Institute of Virology - Viral Immunopathology, Faculty of Medicine, Technical University Munich
contact email	andreas.pichlmair@tum.de
lab head
Pietro Scaturro
contact affiliation	Technical University Munich, Department of Virology
contact email	pietro.scaturro@tum.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/03/PXD012275

PRIDE project URI

• PRIDE
  1. PXD012275
     1. Label: PRIDE project
     2. Name: FluAV vRNP interactome