PXD012220

PXD012220 is an original dataset announced via ProteomeXchange.

Title	Effects of CerS4 deletion in murine epidermis on proteome and lipidome
Description	Epidermal deletion of the lipid modifying enzyme CerS4 causes epidermal barrier impairments associated with human skin diseases. Proteomes of Wt newborn and P47 mice were compared in order to identify molecular differences between barrier formation and maintenance. Proteomes of epidermal splits from Ctr and CerS4epi-/- at different ages (P21, P33, P47) were compared, to identify the effect of CerS4 on barrier maintenance.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:52:01.363.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Frederik Tellkamp
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-01-02 07:28:03	ID requested
1	2020-02-27 05:51:51	announced
⏵ 2	2024-10-22 04:52:09	announced	2024-10-22: Updated project metadata.

10.1016/j.jid.2020.02.006;

Peters F, Tellkamp F, Brodesser S, Wachsmuth E, Tosetti B, Karow U, Bloch W, Uterm, ö, hlen O, Kr, ö, nke M, Niessen CM, Murine Epidermal Ceramide Synthase 4 Is a Key Regulator of Skin Barrier Homeostasis. J Invest Dermatol, 140(10):1927-1937.e5(2020) [pubmed]

curator keyword: Biological

submitter keyword: epidermal barrier, lipid homeostasis, barrier maintenance, barrier formation,CerS4, Ceramides

Carien M. Niessen
contact affiliation	Department of Dermatology, University of Cologne, Cologne
contact email	ait91@uni-koeln.de
lab head
Frederik Tellkamp
contact affiliation	Institute for Genetics, University of Cologne
contact email	ftellka1@uni-koeln.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/02/PXD012220

PRIDE project URI

• PRIDE
  1. PXD012220
     1. Label: PRIDE project
     2. Name: Effects of CerS4 deletion in murine epidermis on proteome and lipidome