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PXD012220

PXD012220 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleEffects of CerS4 deletion in murine epidermis on proteome and lipidome
DescriptionEpidermal deletion of the lipid modifying enzyme CerS4 causes epidermal barrier impairments associated with human skin diseases. Proteomes of Wt newborn and P47 mice were compared in order to identify molecular differences between barrier formation and maintenance. Proteomes of epidermal splits from Ctr and CerS4epi-/- at different ages (P21, P33, P47) were compared, to identify the effect of CerS4 on barrier maintenance.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:52:01.363.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterFrederik Tellkamp
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-01-02 07:28:03ID requested
12020-02-27 05:51:51announced
22024-10-22 04:52:09announced2024-10-22: Updated project metadata.
Publication List
10.1016/j.jid.2020.02.006;
Peters F, Tellkamp F, Brodesser S, Wachsmuth E, Tosetti B, Karow U, Bloch W, Uterm, ö, hlen O, Kr, ö, nke M, Niessen CM, Murine Epidermal Ceramide Synthase 4 Is a Key Regulator of Skin Barrier Homeostasis. J Invest Dermatol, 140(10):1927-1937.e5(2020) [pubmed]
Keyword List
curator keyword: Biological
submitter keyword: epidermal barrier, lipid homeostasis, barrier maintenance, barrier formation,CerS4, Ceramides
Contact List
Carien M. Niessen
contact affiliationDepartment of Dermatology, University of Cologne, Cologne
contact emailait91@uni-koeln.de
lab head
Frederik Tellkamp
contact affiliationInstitute for Genetics, University of Cologne
contact emailftellka1@uni-koeln.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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