PXD012207

PXD012207 is an original dataset announced via ProteomeXchange.

Title	Glioblastoma serum biomarkers identification by iTRAQ
Description	Glioblastoma (GBM) is the most aggressive form of astrocytoma and is difficult to diagnose at early stage. In this study, our goal is to find and validate biomarkers for GBM through serum proteome expression profiling, which would assist in the early diagnosis, and management of GBMs. In the discovery phase, we performed shotgun proteomics of control and GBM pooled serum samples using untargeted 4-plex iTRAQ (isobaric Tags for Relative and Absolute Quantitation) mass spectrometry to identify candidate biomarkers with differential abundance The two candidates, S100A8 and S100A9 were prioritized for verification based on their maximal abundance in GBM serum in our discovery phase.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:51:59.852.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Anjali Arora
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iTRAQ4plex-116 reporter+balance reagent acylated residue; phosphorylated residue; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	LTQ Orbitrap XL; LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2019-01-02 00:21:25	ID requested
1	2019-03-04 02:32:38	announced
⏵ 2	2024-10-22 04:52:08	announced	2024-10-22: Updated project metadata.

Arora A, Patil V, Kundu P, Kondaiah P, Hegde AS, Arivazhagan A, Santosh V, Pal D, Somasundaram K, Serum biomarkers identification by iTRAQ and verification by MRM: S100A8/S100A9 levels predict tumor-stroma involvement and prognosis in Glioblastoma. Sci Rep, 9(1):2749(2019) [pubmed]

10.1038/s41598-019-39067-8;

curator keyword: Biomedical

submitter keyword: Human, glioblastoma, Serum, iTRAQ, GBM

Prof. Kumaraval Somasundaram
contact affiliation	Professor at Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India
contact email	skumar1@iisc.ac.in
lab head
Anjali Arora
contact affiliation	Research Associate
contact email	anjaliarora@iisc.ac.in
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/03/PXD012207

PRIDE project URI

• PRIDE
  1. PXD012207
     1. Label: PRIDE project
     2. Name: Glioblastoma serum biomarkers identification by iTRAQ