PXD012179 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Identification of novel CSF biomarkers in GRN-associated frontotemporal dementia by proteomics |
Description | Frontotemporal dementia is the second most common form of presenile dementia and autosomal dominant inheritance is present in 20-30% of cases, with mutations in granulin (GRN) as a major cause. The exact pathophysiological mechanism by which GRN mutations lead to neurodegeneration is poorly understood. We aimed to identify novel cerebrospinal fluid (CSF) biomarkers in GRN-associated frontotemporal dementia using shotgun proteomics. We included CSF from presymptomatic and symptomatic GRN mutation carriers and healthy non-carriers (controls). We validated our discovery proteomics results in a large international cohort of GRN-mutation carriers and other forms of genetic FTD (C9orf72- and MAPT-mutation carriers) by parallel reaction monitoring. |
HostingRepository | PRIDE |
AnnounceDate | 2019-05-02 |
AnnouncementXML | Submission_2019-05-02_07:11:04.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD012179 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Christoph Stingl |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | Label:13C(6)15N(2); Label:13C(6)15N(4); Oxidation |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-12-24 02:15:50 | ID requested | |
⏵ 1 | 2019-05-02 07:11:06 | announced | |
Publication List
van der Ende EL, Meeter LH, Stingl C, van Rooij JGJ, Stoop MP, Nijholt DAT, Sanchez-Valle R, Graff C, Ö, ijerstedt L, Grossman M, McMillan C, Pijnenburg YAL, Laforce R, Binetti G, Benussi L, Ghidoni R, Luider TM, Seelaar H, van Swieten JC, Novel CSF biomarkers in genetic frontotemporal dementia identified by proteomics. Ann Clin Transl Neurol, 6(4):698-707(2019) [pubmed] |
Keyword List
submitter keyword: Frontotemporal dementia, biomarkers, progranulin, proteomics, mass spectrometry, PRM |
Contact List
Theo M. Luider |
contact affiliation | Head of Laboratory of Neuro-Oncology, Neurology, Clinical & Cancer Proteomics |
contact email | t.luider@erasmusmc.nl |
lab head | |
Christoph Stingl |
contact affiliation | Erasmus MC Rotterdam Department of Neurology |
contact email | c.stingl@erasmusmc.nl |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD012179
- Label: PRIDE project
- Name: Identification of novel CSF biomarkers in GRN-associated frontotemporal dementia by proteomics