PXD012081

PXD012081 is an original dataset announced via ProteomeXchange.

Title	Wnt-modulated hiPSC-derived insulin-producing cells, adult human islet proteome
Description	We aimed to assess whether Wnt-modulation could contribute to mature hiPSC-derived insulin-producing cells in vitro. Building our hypothesis on our previous findings of Wnt activation in immature hiPSC-derived insulin-producing cells compared to adult human islets and with recent data reporting a link between Wnt/PCP and in vitro beta-cell maturation. In this study we stimulated hiPSC-derived insulin-producing cells with syntetic proteins including WNT3A, WNT4, WNT5A and WNT5B as well as inhibiting endogeneous Wnt signaling with Tankyrase inhibitor G007-LK.
HostingRepository	PRIDE
AnnounceDate	2019-11-13
AnnouncementXML	Submission_2019-11-12_16:07:01.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Heidrun Vethe
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2018-12-17 06:25:11	ID requested
⏵ 1	2019-11-12 16:07:02	announced

Vethe H, Ghila L, Berle M, Hoareau L, Haaland Ø A, Scholz H, Paulo JA, Chera S, R, æ, der H, The Effect of Wnt Pathway Modulators on Human iPSC-Derived Pancreatic Beta Cell Maturation. Front Endocrinol (Lausanne), 10():293(2019) [pubmed]

submitter keyword: Human, LC-MS3

Helge Ræder
contact affiliation	Department of Clinical Science, University of Bergen, Bergen, Norway Department of Pediatrics, Haukeland University Hospital, Bergen, Norway
contact email	Helge.Rader@uib.no
lab head
Heidrun Vethe
contact affiliation	Universitetet i Bergen
contact email	heidrun.vethe@uib.no
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/11/PXD012081

PRIDE project URI

• PRIDE
  1. PXD012081
     1. Label: PRIDE project
     2. Name: Wnt-modulated hiPSC-derived insulin-producing cells, adult human islet proteome