PXD012065

PXD012065 is an original dataset announced via ProteomeXchange.

Title	The Effect of Fatty Acids in Hepatic Insulin Resistance - Part 1
Description	Monounsaturated fatty acid (MUFA) oleic acid (OA) has been reported to restore saturated fatty acid palmitic acid (PA)-induced hepatic insulin resistance (IR). However, the detailed molecular mechanism remains elusive. In addition, -3 polyunsaturated fatty acid (PUFA) such as Eicosapentaenoic acid (EPA) has also exerted opposite effects to PA in muscle IR. But whether it plays the same role in hepatic IR and the possible mechanism involved needs to be further explored. Here, we compared the proteome change of HepG2 cells after different fatty acids treatment.
HostingRepository	PRIDE
AnnounceDate	2019-07-11
AnnouncementXML	Submission_2019-07-10_19:35:32.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yaping Sun
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-12-14 03:19:32	ID requested
⏵ 1	2019-07-10 19:35:32	announced

Dataset with its publication pending

submitter keyword: Fatty acids

Insulin resistance

PA

EPA

Fuquan Yang
contact affiliation	1 Key Laboratory of Protein and Peptide Pharmaceuticals & Laboratory of Proteomics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China 2 University of Chinese Academy of Sciences, Beijing 100049, China
contact email	fqyang@ibp.ac.cn
lab head
Yaping Sun
contact affiliation	the institute of biophysics chinese academy of science
contact email	jiayou1989@126.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/07/PXD012065

PRIDE project URI

• PRIDE
  1. PXD012065
     1. Label: PRIDE project
     2. Name: The Effect of Fatty Acids in Hepatic Insulin Resistance - Part 1