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PXD012039

PXD012039 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleHeparin-binding proteome in normal pancreas and murine experimental pancreatitis_C4PR_LIV
DescriptionAcute pancreatitis (AP) is acute inflammation of the pancreas, mainly caused by gallstones and alcohol, driven by changes in communication between cells. Heparin-binding proteins (HBPs) play a central role in cell communication. Therefore, we used heparin affinity proteomics to identify extracellular HBPs in pancreas and plasma of normal mice and in a caerulein mouse model of AP. Many new extracellular HBPs (360) were discovered in the pancreas, taking the total number of HBPs known to 786. Extracellular pancreas HBPs form highly interconnected protein-protein interaction networks in both normal pancreas (NP) and AP. Thus, HBPs represent an important set of extracellular proteins with significant regulatory potential in the pancreas. HBPs in NP are associated with biological functions such as molecular transport and cellular movement that underlie pancreatic homeostasis. However, in AP HBPs are associated with additional processes such as acute phase response signalling, complement activation and mitochondrial dysfunction. Plasma HBPs in AP included known AP biomarkers such as serum amyloid A, as well as emerging targets such as histone H2A. Pancreas HBPs are extracellular and so easily accessible and are potential drug targets in AP, whereas plasma HBPs represent potential biomarkers for AP.
HostingRepositoryPRIDE
AnnounceDate2018-12-17
AnnouncementXMLSubmission_2019-06-20_03:36:51.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD012039
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterDeborah Simpson
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListOxidation; Carbamidomethyl
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-12-13 01:01:54ID requested
12018-12-17 07:24:43announced
22019-06-20 03:37:11announcedUpdated publication reference for PubMed record(s): 31211768.
Publication List
Nunes QM, Su D, Brownridge PJ, Simpson DM, Sun C, Li Y, Bui TP, Zhang X, Huang W, Rigden DJ, Beynon RJ, Sutton R, Fernig DG, The heparin-binding proteome in normal pancreas and murine experimental acute pancreatitis. PLoS One, 14(6):e0217633(2019) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: Heparin-binding proteins (HBPs), Murine, pancreatitis
Contact List
Professor David G Fernig
contact affiliationProfessor of Biological Chemistry, Dept of Biochemistry, Institute of Integrative Biology, University of Liverpool.
contact emaildgfernig@liverpool.ac.uk
lab head
Deborah Simpson
contact affiliationUniversity of Liverpool
contact emaildsimpson@liverpool.ac.uk
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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