PXD012039

PXD012039 is an original dataset announced via ProteomeXchange.

Title	Heparin-binding proteome in normal pancreas and murine experimental pancreatitis_C4PR_LIV
Description	Acute pancreatitis (AP) is acute inflammation of the pancreas, mainly caused by gallstones and alcohol, driven by changes in communication between cells. Heparin-binding proteins (HBPs) play a central role in cell communication. Therefore, we used heparin affinity proteomics to identify extracellular HBPs in pancreas and plasma of normal mice and in a caerulein mouse model of AP. Many new extracellular HBPs (360) were discovered in the pancreas, taking the total number of HBPs known to 786. Extracellular pancreas HBPs form highly interconnected protein-protein interaction networks in both normal pancreas (NP) and AP. Thus, HBPs represent an important set of extracellular proteins with significant regulatory potential in the pancreas. HBPs in NP are associated with biological functions such as molecular transport and cellular movement that underlie pancreatic homeostasis. However, in AP HBPs are associated with additional processes such as acute phase response signalling, complement activation and mitochondrial dysfunction. Plasma HBPs in AP included known AP biomarkers such as serum amyloid A, as well as emerging targets such as histone H2A. Pancreas HBPs are extracellular and so easily accessible and are potential drug targets in AP, whereas plasma HBPs represent potential biomarkers for AP.
HostingRepository	PRIDE
AnnounceDate	2018-12-17
AnnouncementXML	Submission_2019-06-20_03:36:51.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD012039
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Deborah Simpson
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	Oxidation; Carbamidomethyl
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-12-13 01:01:54	ID requested
1	2018-12-17 07:24:43	announced
⏵ 2	2019-06-20 03:37:11	announced	Updated publication reference for PubMed record(s): 31211768.

Nunes QM, Su D, Brownridge PJ, Simpson DM, Sun C, Li Y, Bui TP, Zhang X, Huang W, Rigden DJ, Beynon RJ, Sutton R, Fernig DG, The heparin-binding proteome in normal pancreas and murine experimental acute pancreatitis. PLoS One, 14(6):e0217633(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: Heparin-binding proteins (HBPs), Murine, pancreatitis

Professor David G Fernig
contact affiliation	Professor of Biological Chemistry, Dept of Biochemistry, Institute of Integrative Biology, University of Liverpool.
contact email	dgfernig@liverpool.ac.uk
lab head
Deborah Simpson
contact affiliation	University of Liverpool
contact email	dsimpson@liverpool.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/12/PXD012039

PRIDE project URI

• PRIDE
  1. PXD012039
     1. Label: PRIDE project
     2. Name: Heparin-binding proteome in normal pancreas and murine experimental pancreatitis_C4PR_LIV