PXD012034

PXD012034 is an original dataset announced via ProteomeXchange.

Title	Analysis of plasma proteome of pregnant women with polycystic ovary syndrome (PCOS
Description	Polycystic ovary syndrome (PCOS) is the most common endocrinological disorder of fertile-aged women. PCOS has been associated with adverse pregnancy outcomes and abnormalities of the placenta. By taking a quantitative label-free quantitative proteomics approach we set out to investigate if changes in the plasma proteome of pregnant women with PCOS could elucidate the mechanisms behind the pathologies observed in PCOS pregnancies. We have performed label-free quantitative proteomics on plasma samples from pregnant women with PCOS at term (n=14) and plasma samples from pregnant control women (n = 23) matched for age, gestational length and BMI. The samples are derived from BASIC pregnancy cohort from Uppsala, Sweden. A total of 169 proteins with two or more unique peptides were identified.
HostingRepository	PRIDE
AnnounceDate	2019-11-25
AnnouncementXML	Submission_2019-12-02_02:29:18.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD012034
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Sakari Joenväärä
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Ammonia-loss; Dehydrated; Oxidation; Carbamidomethyl
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2018-12-12 07:50:49	ID requested
1	2019-11-25 09:45:50	announced
⏵ 2	2019-12-02 02:29:19	announced	2019-12-02: Updated publication reference for PubMed record(s): 31772271.

Arffman RK, Saraswat M, Joenv, ä, ä, r, ä S, Khatun M, Agarwal R, Tohmola T, Sundstr, ö, m-Poromaa I, Renkonen R, Piltonen TT, Thromboinflammatory changes in plasma proteome of pregnant women with PCOS detected by quantitative label-free proteomics. Sci Rep, 9(1):17578(2019) [pubmed]

submitter keyword: PCOS, pregnant, MSE, UDMSE, Proteomics

Terhi T. Piltonen
contact affiliation	Department of Obstetrics and Gynecology PEDEGO Research Unit, Medical Research Center Oulu University Hospital, University of Oulu Kajaanintie 50, BOX 5000, 90014 Oulu, FINLAND
contact email	terhi.piltonen@oulu.fi
lab head
Sakari Joenväärä
contact affiliation	Helsinki University
contact email	sakari.joenvaara@helsinki.fi
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/11/PXD012034

PRIDE project URI

• PRIDE
  1. PXD012034
     1. Label: PRIDE project
     2. Name: Analysis of plasma proteome of pregnant women with polycystic ovary syndrome (PCOS