PXD012024

PXD012024 is an original dataset announced via ProteomeXchange.

Title	Dual targeting of BCR-ABL1 and IRE1α is a promising therapeutic strategy in Ph+ ALL
Description	BCR-ABL positive acute lymphoblastic leukemia (ALL) cell survival is strongly dependent on the IRE1α-XBP1 branch of the Unfolded Protein Response (UPR). In the study at hand, we have focused on exploring the link between BCR-ABL1 and IRE1α to better understand whether a simultaneous pharmacological inhibition of both pathways could represent a beneficial therapeutic strategy in Philadelphia positive (Ph+) ALL. Therefore, the effect on the phosphoproteome of two inhibitors (MKC-8866 and Nilotinib) as well as a combination of both compounds was analysed in this study.
HostingRepository	PRIDE
AnnounceDate	2020-09-22
AnnouncementXML	Submission_2020-09-22_04:19:55.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Christian Preisinger
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2018-12-12 00:06:09	ID requested
⏵ 1	2020-09-22 04:19:56	announced

Vieri M, Preisinger C, Schemionek M, Salimi A, Patterson JB, Samali A, Br, ü, mmendorf TH, Appelmann I, Kharabi Masouleh B, induces synthetic lethality in Philadelphia-positive acute lymphoblastic leukemia. Carcinogenesis, 42(2):272-284(2021) [pubmed]

curator keyword: Biomedical

submitter keyword: BCR-ABL1, Cell Death, IRE1α, MAP Kinase, Ph+ ALL, treatment

Iris Appelmann
contact affiliation	Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, RWTH Aachen University Medical School, Aachen, Germany,
contact email	iappelmann@ukaachen.de
lab head
Christian Preisinger
contact affiliation	Proteomics Facility, IZKF Aachen, University Clinic RWTH Aachen
contact email	cpreisinger@ukaachen.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/09/PXD012024

PRIDE project URI

• PRIDE
  1. PXD012024
     1. Label: PRIDE project
     2. Name: Dual targeting of BCR-ABL1 and IRE1α is a promising therapeutic strategy in Ph+ ALL