PXD011934

PXD011934 is an original dataset announced via ProteomeXchange.

Title	Identification of mitochondrial dysfunction in rheumatoid arthritis patients
Description	Immune cells are majorly dysregulated in rheumatoid arthritis patients and are a major cause of pathogenesis and progression of this autoimmune condition. As mitochondria are master regulators of metabolism of all cells present in human body, it is of prime importance to study mitochondrial homeostasis in immune cells for identifying any dysfunction contributing to pathogenesis or progression of RA. The objective of our study is to understand the mitochondrial and mitochondrially driven alterations in immune cells of RA patients which may cause them to perform abnormal functions and may have an important contribution in progression of the disease.
HostingRepository	PRIDE
AnnounceDate	2020-06-22
AnnouncementXML	Submission_2020-06-21_22:28:55.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Bhawna Gupta
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iTRAQ8plex-116 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2018-12-04 08:29:07	ID requested
⏵ 1	2020-06-21 22:28:55	announced

Khanna S, Padhan P, Jaiswal KS, Jain AP, Ghosh A, Tripathy A, Gowda H, Raghav SK, Gupta B, Altered mitochondrial proteome and functional dynamics in patients with rheumatoid arthritis. Mitochondrion, 54():8-14(2020) [pubmed]

submitter keyword: Rheumatoid arthritis, PBMCs, mitochondrial dysfunction, proteins

Dr. Bhawna Gupta
contact affiliation	Disease Biology Lab School of Biotechnology, Campus 11 KIIT Deemed to be University Bhubaneswar Odisha
contact email	bhawna.gupta@kiitbiotech.ac.in
lab head
Bhawna Gupta
contact affiliation	School of Biotechnology, KIIT
contact email	bhawna.gupta@kiitbiotech.ac.in
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/06/PXD011934

PRIDE project URI

• PRIDE
  1. PXD011934
     1. Label: PRIDE project
     2. Name: Identification of mitochondrial dysfunction in rheumatoid arthritis patients