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PXD011929 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMeltome Atlas - thermal proteome stability across the tree of life
DescriptionWe have developed a mass spectrometry-based approach that allowed us to quantitatively monitor protein stability across a broad range of temperatures at the proteome scale (meltome). We profiled the meltomes of several microorganisms and eukaryotic species including human, allowing to investigate the determinants of protein thermostability and survival in various environmental niches. Moreover, we will make Meltome Atlas a valuable, publicly available resource for the biological community to investigate their proteins of interest in the context of protein thermostbility.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAnna Jarzab
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Arabidopsis thaliana (Mouse-ear cress); NCBI TaxID: 3702; scientific name: Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579); NCBI TaxID: 300852; scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932; scientific name: Picrophilus torridus; NCBI TaxID: 82076; scientific name: Geobacillus stearothermophilus; NCBI TaxID: 391290; scientific name: Escherichia coli; NCBI TaxID: 562; scientific name: Caenorhabditis elegans; NCBI TaxID: 6239; scientific name: Bacillus subtilis; NCBI TaxID: 1423; scientific name: Oleispira antarctica; NCBI TaxID: 188908; scientific name: Homo sapiens (Human); NCBI TaxID: 9606; scientific name: Danio rerio (Zebrafish) (Brachydanio rerio); NCBI TaxID: 7955; scientific name: Drosophila melanogaster (Fruit fly); NCBI TaxID: 7227;
ModificationListmethionine oxidation with neutral loss of 64 Da; acetylated residue
InstrumentOrbitrap Fusion Lumos; iTRAQ reagent 116
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-12-03 23:15:23ID requested
12020-04-29 00:34:02announced
Publication List
Jarzab A, Kurzawa N, Hopf T, Moerch M, Zecha J, Leijten N, Bian Y, Musiol E, Maschberger M, Stoehr G, Becher I, Daly C, Samaras P, Mergner J, Spanier B, Angelov A, Werner T, Bantscheff M, Wilhelm M, Klingenspor M, Lemeer S, Liebl W, Hahne H, Savitski MM, Kuster B, Meltome atlas-thermal proteome stability across the tree of life. Nat Methods, 17(5):495-503(2020) [pubmed]
Keyword List
curator keyword: Technical, Biological
submitter keyword: Meltome Atlas, melting point, thermostability, Thermal Proteome Profiling, protein stability
Contact List
Bernhard Kuster
contact affiliationTechnical University of Munich
contact emailkuster@tum.de
lab head
Anna Jarzab
contact affiliationTechnical University of Munich
contact emailanna.jarzab@tum.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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