PXD011927

PXD011927 is an original dataset announced via ProteomeXchange.

Title	A. nidulans STRIPAK
Description	Eukaryotic striatin forms striatin-interacting phosphatase and kinase (STRIPAK) complexes that control many cellular processes including development, cellular transport, signal transduction, stem cell differentiation and cardiac functions. However, detailed knowledge of complex assembly and its roles in stress responses are currently poorly understood. Here, we discovered six striatin (StrA) interacting proteins, which form a heptameric complex in the filamentous fungus Aspergillus nidulans. The main components are: scaffold StrA (striatin), further components SipA (Mob3), SipB (SIKE-like), SipC (STRIP1/2), SipD (SLMAP), catalytic (SipE, PP2Ac) and regulatory (SipF, PP2AA) phosphatase subunits. The STRIPAK complex, which is established during vegetative growth and maintained during the early hours of light and dark development, is formed on the nuclear envelope in the presence of scaffold StrA. The loss of striatin revealed three STRIPAK subcomplexes: (I) SipA only interacts with StrA, (II) SipB-SipD is found as a heterodimer, (III) SipC, SipE and SipF exist as a heterotrimeric complex.
HostingRepository	PRIDE
AnnounceDate	2019-03-12
AnnouncementXML	Submission_2019-03-25_02:51:26.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ozgur Bayram
SpeciesList	scientific name: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans); NCBI TaxID: 227321;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-12-03 08:28:11	ID requested
1	2019-03-11 23:15:50	announced
⏵ 2	2019-03-25 02:51:28	announced	Updated publication reference for PubMed record(s): 30883543.

Elramli N, Karahoda B, Sarikaya-Bayram Ö, Frawley D, Ulas M, Oakley CE, Oakley BR, Seiler S, Bayram Ö, Assembly of a heptameric STRIPAK complex is required for coordination of light-dependent multicellular fungal development with secondary metabolism in Aspergillus nidulans. PLoS Genet, 15(3):e1008053(2019) [pubmed]

curator keyword: Biological

submitter keyword: A. nidulans, LC-MSMS

Ozgur Bayram
contact affiliation	Fungal genetics and secondary metabolism laboratory, Maynooth University, Biology Department, Callan Building, Maynooth, Co. Kildare, Ireland
contact email	ozgur.bayram@mu.ie
lab head
Ozgur Bayram
contact affiliation	Dr.
contact email	ozgur.bayram@mu.ie
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/03/PXD011927

PRIDE project URI

• PRIDE
  1. PXD011927
     1. Label: PRIDE project
     2. Name: A. nidulans STRIPAK