PXD011895
PXD011895 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Quantitative Proteomic Atlas of Ubiquitination in Hepatocellular Carcinoma |
| Description | Ubiquitination plays a critical role in human hepatocellular carcinoma (HCC) genesis and metastasis, but how these processes affect systemic ubiquitinome still remains unclear. In this study, our dataset of around 12,000 diGly modified sites was identified providing a valuable insight into HCC. We find both the diGly sites and ubiquitin chains undergo bulk increase in HCC, suggesting the boost of diGly modification activities in tumor genesis. Two of the most significant alterations of ubiquitination modification in HCC concern components of proteasome and antigen presentation activity. Moreover, during the progression of HCC metastasis, we discover a more extensive diGly modified sites with shorter ubiquitin chains and reveal the key role of ubiquitination modification on proteins involving cell-cell adhesion. |
| HostingRepository | iProX |
| AnnounceDate | 2020-04-14 |
| AnnouncementXML | Submission_2023-03-01_19:13:39.724.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Feiyang Ji |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | ubiquitination signature dipeptidyl lysine |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2018-11-29 21:10:03 | ID requested | |
| 1 | 2019-12-30 19:48:46 | announced | |
| 2 | 2020-04-14 22:02:48 | announced | 2020-04-15: Update datafiles |
| ⏵ 3 | 2023-03-01 19:13:40 | announced | 2020-04-15: Update datafiles 2023-03-02: Update publication information. |
Publication List
| Ji F, Zhou M, Sun Z, Jiang Z, Zhu H, Xie Z, Ouyang X, Zhang L, Li L, Integrative proteomics reveals the role of E3 ubiquitin ligase SYVN1 in hepatocellular carcinoma metastasis. Cancer Commun (Lond), 41(10):1007-1023(2021) [pubmed] |
Keyword List
| submitter keyword: Ubiquitination, Hepatocellular Carcinoma |
Contact List
| Lanjuan Li | |
|---|---|
| contact affiliation | State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University |
| contact email | ljli@zju.edu.cn |
| lab head | |
| Feiyang Ji | |
| contact affiliation | State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University |
| contact email | feiyangji@zju.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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