PXD011821

PXD011821 is an original dataset announced via ProteomeXchange.

Title	A region-resolved mucosa proteome of the human stomach
Description	The human gastric mucosa is the most active and functional layer that carries out food digestion and metabolic processes in physiological conditions and also the main origin of carcinogenesis in gastric cancer. Anatomically, the human stomach is divided into 7 regions with physiological functions, but the protein basis for cellular specialization is not well understood. Here we present a global analysis of protein profiles of 80 apparently normal mucosas obtained by endoscopic biopsy of stomach. We identified 11,597 proteins and provided an estimation of protein expression variations/ranges in the 7 regions of the human stomach. To our knowledge, this is the first region-resolved, near normal tissue proteome reference map obtained from living individuals. We also measured mucosa protein profiles of tumor and tumor nearby tissues (TNT) from 54 gastric cancer patients, allowing for comparisons between tumor, TNT, and normal tissues. These datasets provide a rich resource for the gastrointestinal tract research community to investigate the molecular basis for region specific functions in mucosa physiology and pathology including gastric cancer.
HostingRepository	iProX
AnnounceDate	2018-11-26
AnnouncementXML	Submission_2019-08-14_23:47:26.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xiaotian Ni
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	acetylated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2018-11-25 23:22:44	ID requested
1	2018-11-25 23:33:59	announced
⏵ 2	2019-08-14 23:52:35	announced	update publication information.

Ni X, Tan Z, Ding C, Zhang C, Song L, Yang S, Liu M, Jia R, Zhao C, Song L, Liu W, Zhou Q, Gong T, Li X, Tai Y, Zhu W, Shi T, Wang Y, Xu J, Zhen B, Qin J, A region-resolved mucosa proteome of the human stomach. Nat Commun, 10(1):39(2019) [pubmed]

submitter keyword: Human stomach, Mucosa, Proteome, Gastric cancer

Jun Qin
contact affiliation	State Key Laboratory of Proteomics, Beijing Proteome Research Center; National Center for Protein Sciences (The PHOENIX center, Beijing)
contact email	jqin@bcm.edu
lab head
Xiaotian Ni
contact affiliation	State Key Laboratory of Proteomics, Beijing Proteome Research Center; National Center for Protein Sciences (The PHOENIX center, Beijing)
contact email	xiaotian-ni@qq.com
dataset submitter

iProX dataset URI