PXD011796

PXD011796 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of neutrophil extracellular traps (healthy control, rheumatoid arthritis, systemic lupus erythematosus)_C4PR_LIV
Description	Neutrophil Extracellular Traps (NETs) are chromatin-derived extracellular structures that are expelled from neutrophils in response to infectious or inflammatory stimuli. NET DNA structures are decorated with proteins including histones, myeloperoxidase and neutrophil elastase. NETs are implicated in the development of auto-immunity in diseases including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) through the externalisation of intracellular neoepitopes e.g. dsDNA and nuclear proteins in SLE and citrullinated peptides in RA. The aim of this work was to use quantitative proteomics to identify and measure NET proteins produced by neutrophils from healthy individuals, and from patients with RA and SLE.
HostingRepository	PRIDE
AnnounceDate	2019-02-18
AnnouncementXML	Submission_2019-04-01_00:27:32.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD011796
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Deborah Simpson
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Oxidation; Carbamidomethyl
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-11-22 01:52:34	ID requested
1	2019-02-18 06:53:07	announced
⏵ 2	2019-04-01 00:27:33	announced	Updated publication reference for PubMed record(s): 30915077.

Chapman EA, Lyon M, Simpson D, Mason D, Beynon RJ, Moots RJ, Wright HL, Caught in a Trap? Proteomic Analysis of Neutrophil Extracellular Traps in Rheumatoid Arthritis and Systemic Lupus Erythematosus. Front Immunol, 10():423(2019) [pubmed]

submitter keyword: Neutrophil extracellular traps, PMA, A23187, rheumatoid arthritis, systemic lupus erythematosus

Dr Helen L Wright
contact affiliation	Arthritis Research UK Career Development Fellow Institute of Aging and Chronic Disease University of Liverpool
contact email	hlwright@liverpool.ac.uk
lab head
Deborah Simpson
contact affiliation	University of Liverpool
contact email	dsimpson@liverpool.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/02/PXD011796

PRIDE project URI

• PRIDE
  1. PXD011796
     1. Label: PRIDE project
     2. Name: Proteomic analysis of neutrophil extracellular traps (healthy control, rheumatoid arthritis, systemic lupus erythematosus)_C4PR_LIV