PXD011761

PXD011761 is an original dataset announced via ProteomeXchange.

Title	Disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity
Description	Kinase inhibitors (KIs) used in cancer therapeutics are associated with various side effects. One of the most significant adverse events that lead to discontinuation or modification of treatment is nephrotoxicity. We have identified BCR-ABL1 inhibitor dasatinib as a potential glomerular nephrotoxin due to its direct effect on podocyte biophysics. In order to understand the underlying molecular mechanisms used phospho-tyrosine enriched shotgun proteomics in immortalized mouse kidney podocytes treated with dasatinib.
HostingRepository	PRIDE
AnnounceDate	2019-03-29
AnnouncementXML	Submission_2019-05-27_02:02:04.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD011761
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Tong Liu
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	Phospho; Oxidation; Carbamidomethyl
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-11-20 05:12:03	ID requested
1	2019-03-29 12:47:59	announced
⏵ 2	2019-05-27 02:02:06	announced	Updated publication reference for PubMed record(s): 31053734.

Calizo RC, Bhattacharya S, van Hasselt JGC, Wei C, Wong JS, Wiener RJ, Ge X, Wong NJ, Lee JJ, Cuttitta CM, Jayaraman G, Au VH, Janssen W, Liu T, Li H, Salem F, Jaimes EA, Murphy B, Campbell KN, Azeloglu EU, Disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity. Nat Commun, 10(1):2061(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: Podocyte

kidney

dasatinib

BCR-ABL

nephrotoxicity

cytoskeleton

actin

biophysics

Evren U. Azeloglu
contact affiliation	Department of Medicine, Nephrology and Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
contact email	evren.azeloglu@mssm.edu
lab head
Tong Liu
contact affiliation	Rutgers University
contact email	linto@njms.rutgers.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/03/PXD011761

PRIDE project URI

• PRIDE
  1. PXD011761
     1. Label: PRIDE project
     2. Name: Disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity