PXD011744

PXD011744 is an original dataset announced via ProteomeXchange.

Title	Effect of Juvenile Environmental Tobacco Smoke Exposure on the Rat Frontal Cortex Neuroproteome
Description	Exposure to secondhand tobacco smoke during early childhood has been linked with an increased risk for behavioral disorders, yet little is known regarding how brain development is impacted. Using an environmental tobacco smoke (ETS) passive inhalation model, this study assesses the neurodevelopmental impact of juvenile exposure during a critical period of frontal cortex development, specifically that of the rat orbital neocortex between postnatal days 8 and 22. Agnostic shotgun proteomics was employed to discern the biomolecular shift within this rapidly developing brain region that is responsible for higher-order behavioral control. The orbital cortex neuroproteome was assessed between ETS-exposed and room-air control animals employing a label-free shotgun approach with data-independent acquisition. Following protein roll-up, a total of X protein were found statistically altered in quantity out of Y total proteins identified. These results implicate a prominent shift within metabolic processes and synaptic organization related to excitatory and inhibitory neurotransmission. Findings derived from this dataset may further our understanding of how secondhand smoke exposure can perturb the orbital frontal cortex and result in developmental behavioral disorders.
HostingRepository	PRIDE
AnnounceDate	2018-12-17
AnnouncementXML	Submission_2018-12-17_05:44:32.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD011744
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Andrew Ottens
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	Phospho; Methyl; Oxidation; Carbamidomethyl
Instrument	Synapt G2 HDMS

Revision	Datetime	Status	ChangeLog Entry
0	2018-11-19 08:41:28	ID requested
⏵ 1	2018-12-17 05:44:33	announced

Lewis LSC, Muldoon PP, Pilaka PP, Ottens AK, Frontal Cortex Proteome Perturbation after Juvenile Rat Secondhand Smoke Exposure. Proteomics, 18(24):e1800268(2018) [pubmed]

curator keyword: Biomedical

submitter keyword: Rat, Brain, Frontal, Cortex, Juvenile, Development, Neuroproteome, HDMSe, Secondhand Smoke, tobacco

Andrew K Ottens
contact affiliation	Department of Anatomy and Neurobiology Virginia Commonwealth University Richmond, VA 23298-0709 USA
contact email	akottens@vcu.edu
lab head
Andrew Ottens
contact affiliation	Virginia Commonwealth University
contact email	akottens@vcu.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD011744
     1. Label: PRIDE project
     2. Name: Effect of Juvenile Environmental Tobacco Smoke Exposure on the Rat Frontal Cortex Neuroproteome