PXD011736

PXD011736 is an original dataset announced via ProteomeXchange.

Title	Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency
Description	Using co-immunoprecipitation and mass spectrometry analysis we identify unique FLCN binding partners. The interactions of FLCN with components of the mTOR pathway (mTORC1 and mTORC2) reveal a mechanism of FLCN function during exit from naïve pluripotency.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:50:34.292.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Aaron Robitaille
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2018-11-19 08:16:35	ID requested
1	2019-02-13 05:59:44	announced
⏵ 2	2024-10-22 04:50:41	announced	2024-10-22: Updated project metadata.

Mathieu J, Detraux D, Kuppers D, Wang Y, Cavanaugh C, Sidhu S, Levy S, Robitaille AM, Ferreccio A, Bottorff T, McAlister A, Somasundaram L, Artoni F, Battle S, Hawkins RD, Moon RT, Ware CB, Paddison PJ, Ruohola-Baker H, Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency. Nat Commun, 10(1):632(2019) [pubmed]

10.1038/s41467-018-08020-0;

curator keyword: Biological

submitter keyword: Folliculin, mTOR

Hannele Ruohola-Baker
contact affiliation	Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington 98109, USA
contact email	hannele@uw.edu
lab head
Aaron Robitaille
contact affiliation	University of Washington
contact email	arobitaille@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/02/PXD011736

PRIDE project URI

• PRIDE
  1. PXD011736
     1. Label: PRIDE project
     2. Name: Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency