PXD011672

PXD011672 is an original dataset announced via ProteomeXchange.

Title	Activin A and NK cell function
Description	Natural killer (NK) cells are innate lymphocytes that play a major role in immunosurveillance against tumor initiation and metastasis spread. Signals and checkpoints that regulate NK cell fitness and function in the tumor microenvironment are not well defined. Transforming grow factor (TGF)- is a recognized suppressor of NK cells that inhibits IL-15 dependent signaling events and induces cellular transdifferentiation, however the role of other SMAD signaling pathways in NK cells is unknown. We used a global, label-free proteomics approach to compare the protein expression profiles of NK cells in the presence of TGF-b or activin-A.
HostingRepository	PRIDE
AnnounceDate	2020-04-06
AnnouncementXML	Submission_2020-04-06_01:02:58.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Laura Dagley
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	impact II

Revision	Datetime	Status	ChangeLog Entry
0	2018-11-13 01:50:15	ID requested
⏵ 1	2020-04-06 01:03:00	announced

Rautela J, Dagley LF, de Oliveira CC, Schuster IS, Hediyeh-Zadeh S, Delconte RB, Cursons J, Hennessy R, Hutchinson DS, Harrison C, Kita B, Vivier E, Webb AI, Degli-Esposti MA, Davis MJ, Huntington ND, Souza-Fonseca-Guimaraes F, Therapeutic blockade of activin-A improves NK cell function and antitumor immunity. Sci Signal, 12(596):(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: Activin signaling, TGF-b signaling, QTOF, label-free proteomics

Fernando Souza-Fonseca-Guimaraes
contact affiliation	Senior Postdoctoral Fellow, Huntington Laboratory, The Walter and Eliza Hall Institute, Australia
contact email	guimaraes.f@wehi.edu.au
lab head
Laura Dagley
contact affiliation	WEHI
contact email	dagley.l@wehi.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/04/PXD011672

PRIDE project URI

• PRIDE
  1. PXD011672
     1. Label: PRIDE project
     2. Name: Activin A and NK cell function