PXD011614

PXD011614 is an original dataset announced via ProteomeXchange.

Title	Protein-based Cardiogenic Shock Patient Classifier
Description	Cardiogenic shock (CS) is associated with high short-term mortality and a precise CS risk stratification could guide interventions to improve patient outcome. We used mass spectrometry based proteomics to first to a discovery approach to select some biomarker canduidates and then verify them by targeted mass spectrometry (PRM). A 4-protein risk score (CS4P) was derived and validated for 90-day risk of mortality. The CS4P risk score which comprises proteins Liver-fatty acid-binding protein (L-FABP), Beta-2-microglobulin (B2MG), Fructose-bisphosphate aldolase B (ALDOB), and SerpinG1 (IC1), identified short-term mortality risk with a C-statistic of 0.83 (95% CI 0.74–0.89).
HostingRepository	PRIDE
AnnounceDate	2020-11-16
AnnouncementXML	Submission_2020-11-16_14:47:13.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Eva Borràs
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2018-11-07 08:36:52	ID requested
⏵ 1	2020-11-16 14:47:13	announced

Rueda F, Borr, à, s E, Garc, í, a-Garc, í, a C, Iborra-Egea O, Revuelta-L, ó, pez E, Harjola VP, Cediel G, Lassus J, Tarvasm, ä, ki T, Mebazaa A, Sabid, ó E, Bay, é, s-Gen, í, s A, Protein-based cardiogenic shock patient classifier. Eur Heart J, 40(32):2684-2694(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: Cradiogenic shock, proteomics

Eduard Sabidó
contact affiliation	Center for Genomic Regulation (CRG) University Pompeu Fabra (UPF)
contact email	eduard.sabido@crg.eu
lab head
Eva Borràs
contact affiliation	UPF
contact email	eva.borras@upf.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/11/PXD011614

PRIDE project URI

• PRIDE
  1. PXD011614
     1. Label: PRIDE project
     2. Name: Protein-based Cardiogenic Shock Patient Classifier