PXD011576

PXD011576 is an original dataset announced via ProteomeXchange.

Title	Bufffalo serum iTRAQ - Global serum proteomic changes in water buffaloes infected with Fasciola gigantica
Description	Fasciola gigantica infects buffalo in Asian and African countries and causes significant economic losses. As a kind of zoonotic parasite disease, human infection has been reported and make fascioliasis patients suffer heavy abdominal pain, anemia and workforce loss. Fasciola can modulate host immune responses to survive from immune attack and some mechanisms have been reported with its antigen protein. Protein, as the chief actors within the cell, presents the dynamic changes of body with its specific changes and serves as unexceptionable biomarkers in many disease-detections. But there is not any study about serum proteomic for diagnostic target seeking in buffalo after infection with F. gigantica. Herein, Isobaric Tags for Relative and Absolute Quantitation (iTRAQ) and Parallel Reaction Monitoring (PRM) technologies were used in the present study to reveal the dynamic changes of proteins in buffalo serum after infected with F. gigantica. Six proteins were found significantly regulated in all three groups which reminds us that they could be used as new diagnostic biomarkers in buffalo throughout F. gigantica infection. All these are new findings in buffalo after infection with F. gigantica and could provide a new insight into the potential possibility in this parasite clearance.
HostingRepository	PRIDE
AnnounceDate	2021-03-04
AnnouncementXML	Submission_2021-03-04_13:54:59.305.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Fu-Kai Zhang
SpeciesList	scientific name: Bos taurus (Bovine); NCBI TaxID: 9913;
ModificationList	iTRAQ8plex-116 reporter+balance reagent acylated residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2018-11-05 02:30:12	ID requested
⏵ 1	2021-03-04 13:55:00	announced

Zhang FK, Hu RS, Elsheikha HM, Sheng ZA, Zhang WY, Zheng WB, Zhu XQ, He JJ, Global serum proteomic changes in water buffaloes infected with Fasciola gigantica. Parasit Vectors, 12(1):281(2019) [pubmed]

submitter keyword: Buffalo, serum, iTRAQ

Xing-Quan Zhu
contact affiliation	State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province 730046, PR China
contact email	xingquanzhu1@hotmail.com
lab head
Fu-Kai Zhang
contact affiliation	Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences
contact email	kid372820378@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/11/PXD011576

PRIDE project URI

• PRIDE
  1. PXD011576
     1. Label: PRIDE project
     2. Name: Bufffalo serum iTRAQ - Global serum proteomic changes in water buffaloes infected with Fasciola gigantica