PXD011561

PXD011561 is an original dataset announced via ProteomeXchange.

Title	A proteomic approach to identify biomarkers of Glycogen Storage Disease type 1a progression in mouse livers: evidence for metabolic reprogramming, tissue inflammation and macrophage polarization
Description	Glycogen storage disease type 1a (GSD-1a) is an autosomal recessive disorder caused by mutations in the catalytic subunit of the glucose-6-phosphatase-alpha (G6Pase-α). The current treatment of GSD-1a is based on the control of symptomatic hypoglycemia. Long-term complications such as renal failure and development of hepatocellular adenoma/carcinoma develop in the majority of patients. The aim of this study was to determine the proteomic expression changes in the liver of LS-G6pc-/- mice, a mouse model of GSD-1a, in comparison with wild type mice to identify potential biomarkers of the pathophysiology of the affected liver.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:49:54.508.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Andrea Petretto
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2018-11-01 06:48:15	ID requested
1	2019-11-25 01:18:50	announced
⏵ 2	2024-10-22 04:49:54	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: LC-MS/MS

Andrea Petretto
contact affiliation	Ist G. Gaslini
contact email	andreapetretto@gaslini.org
lab head
Andrea Petretto
contact affiliation	Gaslini Children's Hospital
contact email	a.petretto@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/11/PXD011561

PRIDE project URI

• PRIDE
  1. PXD011561
     1. Label: PRIDE project
     2. Name: A proteomic approach to identify biomarkers of Glycogen Storage Disease type 1a progression in mouse livers: evidence for metabolic reprogramming, tissue inflammation and macrophage polarization