PXD011541

PXD011541 is an original dataset announced via ProteomeXchange.

Title	In Search of the Altering Salivary Proteome in Metastatic Breast and Ovarian Cancer
Description	Breast and ovarian cancers, the most common cancers in women in India. Metastatic organotropism is a non-random, predetermined process which represents a more lethal and advanced form of cancer with increased mortality rate. In an attempt to study organotropism, salivary proteins were analyzed by mass spectrometry indicative of pathophysiology of breast and ovarian cancers compared to healthy and ovarian chemotherapy subjects. Collectively, 646 proteins were identified, of which 409 proteins were confidently identified across all four groups. Network analysis of up-regulated proteins such as coronin-1A, hepatoma derived growth factor, vasodilator-stimulated phosphoprotein (VASP), and cofilin in breast cancer and proteins like coronin-1A, destrin and HSP90α in ovarian cancer were functionally linked and were known to regulate cell proliferation and migration. Additionally, proteins namely VASP, coronin-1A, stathmin and suprabasin were confidently identified in ovarian chemotherapy subjects, possibly in response to combined paclitaxel and carboplatin drug therapy to ovarian cancer. In summary, this proteomic study was performed to identify a pattern of differentially expressed salivary proteins as indicators of metastatic organotropism potential of breast and ovarian cancers, as well as their response to neoadjuvant (paclitaxel and carboplatin) drugs therapy.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:05:01.096.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kuldeep Giri
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-10-31 07:41:32	ID requested
1	2020-05-26 12:25:31	announced
⏵ 2	2024-10-22 05:05:08	announced	2024-10-22: Updated project metadata.

10.1096/fba.2018-00029;

Giri K, Mehta A, Ambatipudi K, In search of the altering salivary proteome in metastatic breast and ovarian cancers. FASEB Bioadv, 1(3):191-207(2019) [pubmed]

submitter keyword: Quantitative proteomics, Neoadjuvant Therapy, Organotropism,Saliva

Kiran Ambatipudi
contact affiliation	Assistant Professor, Department of Biotechnology, Indian Institute of Technology, Roorkee,
contact email	kiranfbt@iitr.ac.in
lab head
Kuldeep Giri
contact affiliation	Indian Institute of Technology Roorkee
contact email	goswami8899@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/05/PXD011541

PRIDE project URI

• PRIDE
  1. PXD011541
     1. Label: PRIDE project
     2. Name: In Search of the Altering Salivary Proteome in Metastatic Breast and Ovarian Cancer