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PXD011541

PXD011541 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIn Search of the Altering Salivary Proteome in Metastatic Breast and Ovarian Cancer
DescriptionBreast and ovarian cancers, the most common cancers in women in India. Metastatic organotropism is a non-random, predetermined process which represents a more lethal and advanced form of cancer with increased mortality rate. In an attempt to study organotropism, salivary proteins were analyzed by mass spectrometry indicative of pathophysiology of breast and ovarian cancers compared to healthy and ovarian chemotherapy subjects. Collectively, 646 proteins were identified, of which 409 proteins were confidently identified across all four groups. Network analysis of up-regulated proteins such as coronin-1A, hepatoma derived growth factor, vasodilator-stimulated phosphoprotein (VASP), and cofilin in breast cancer and proteins like coronin-1A, destrin and HSP90α in ovarian cancer were functionally linked and were known to regulate cell proliferation and migration. Additionally, proteins namely VASP, coronin-1A, stathmin and suprabasin were confidently identified in ovarian chemotherapy subjects, possibly in response to combined paclitaxel and carboplatin drug therapy to ovarian cancer. In summary, this proteomic study was performed to identify a pattern of differentially expressed salivary proteins as indicators of metastatic organotropism potential of breast and ovarian cancers, as well as their response to neoadjuvant (paclitaxel and carboplatin) drugs therapy.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:05:01.096.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterKuldeep Giri
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-10-31 07:41:32ID requested
12020-05-26 12:25:31announced
22024-10-22 05:05:08announced2024-10-22: Updated project metadata.
Publication List
10.1096/fba.2018-00029;
Giri K, Mehta A, Ambatipudi K, In search of the altering salivary proteome in metastatic breast and ovarian cancers. FASEB Bioadv, 1(3):191-207(2019) [pubmed]
Keyword List
submitter keyword: Quantitative proteomics, Neoadjuvant Therapy, Organotropism,Saliva
Contact List
Kiran Ambatipudi
contact affiliationAssistant Professor, Department of Biotechnology, Indian Institute of Technology, Roorkee,
contact emailkiranfbt@iitr.ac.in
lab head
Kuldeep Giri
contact affiliationIndian Institute of Technology Roorkee
contact emailgoswami8899@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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