PXD011523

PXD011523 is an original dataset announced via ProteomeXchange.

Title	Proteomics-based identification of SIRT2 interaction partners
Description	The NAD+ dependent deacetylase enzyme SIRT2 functions in diverse cellular processes including the cell cycle, metabolism and has recently been demonstrated to have important roles during tumorigenesis and bacterial infection. Though predominantly localised in the cytoplasm SIRT2 has been shown to continuously cycle in and out of the nucleus where it functions as a histone deacetylase. To investigate the varied and pleiotropic nature of SIRT2 we performed proteomic analyses using liquid chromatography-tandem mass spectrometry to identify novel interacting partners. Using this approach, we have generated a whole cell interactome consisting of over 500 proteins highlighting the distinct cellular processes in which SIRT2 functions.
HostingRepository	PRIDE
AnnounceDate	2020-02-20
AnnouncementXML	Submission_2020-02-20_03:25:54.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Impens Francis
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; monohydroxylated residue; acetylated residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2018-10-30 02:56:01	ID requested
⏵ 1	2020-02-20 03:25:55	announced

Eldridge MJG, Pereira JM, Impens F, Hamon MA, Active nuclear import of the deacetylase Sirtuin-2 is controlled by its C-terminus and importins. Sci Rep, 10(1):2034(2020) [pubmed]

curator keyword: Biological

submitter keyword: SIRT2, AP-MS, nuclear translocation, bacterial infection, tumorigenesis

Mélanie Hamon
contact affiliation	Institut Pasteur, Chromatine et Infection G5, Paris, France
contact email	melanie.hamon@pasteur.fr
lab head
Impens Francis
contact affiliation	VIB Proteomics Core Ghent University
contact email	francis.impens@vib-ugent.be
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/02/PXD011523

PRIDE project URI

• PRIDE
  1. PXD011523
     1. Label: PRIDE project
     2. Name: Proteomics-based identification of SIRT2 interaction partners