PXD011433

PXD011433 is an original dataset announced via ProteomeXchange.

Title	Proteome analysis of CD4+T cells leading to the proposition of a novel mechanism to interpret the impact of bisphenol A on immunity
Description	Environmental estrogens, such as bisphenol A (BPA) that is normally used in the manufacture of food and beverage containers, pose increasingly worrisome hazards to human and wildlife health. The adverse effects of BPA are multifaceted; while close attention has been paid to their effect on the immune response system, especially the possible etiology of asthma in children and adults. The underlined mechanism of how BPA influences the biological pathways to alter the normal immune response system is unknown. Here, we report to use various proteomics and biological experiments to identify BPA-targeting proteins and protein pathways in human cell lines and mouse CD4+T cells. The outcomes of these experiments revealed that the cellular respiration, phagosome maturation and especially the Sirtuin signaling pathways are among the top canonic or KEGG pathways perturbed by BPA.
HostingRepository	PRIDE
AnnounceDate	2022-02-28
AnnouncementXML	Submission_2022-02-28_04:01:45.389.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kangling Zhang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue; deamidated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-10-22 00:57:59	ID requested
⏵ 1	2022-02-28 04:01:45	announced

Dataset with its publication pending

curator keyword: Biomedical

submitter keyword: Proteomics, Bisphenol A, Immune Response, Sting signaling, histone modification

Kangling Zhang
contact affiliation	UTMB
contact email	kazhang@utmb.edu
lab head
Kangling Zhang
contact affiliation	University of Texas Medical Branch
contact email	kazhang@utmb.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD011433
     1. Label: PRIDE project
     2. Name: Proteome analysis of CD4+T cells leading to the proposition of a novel mechanism to interpret the impact of bisphenol A on immunity