PXD011383

PXD011383 is an original dataset announced via ProteomeXchange.

Title	Analysis of the preoperative plasma samples of sinus rhythm and POAF in CABG using Proteomic study
Description	Postoperative atrial fibrillation (POAF) is a common complication in coronary artery bypass grafting (CABG). We investigated pre-existing biological derangements before CABG to provide molecular insights into the pathogenesis. Preoperative plasma samples of discovery set from matched cohorts in sinus rhythm and POAF respectively were analyzed using proteomic approaches to identify the differential proteins that were validated in a new cohort by ELISA. Bioinformatics analysis were performed to reveal the underlying mechanism of the onset of POAF. The results revealed that preoperative alteration of PPAR-alpha increased the susceptibility of POAF after CABG.
HostingRepository	iProX
AnnounceDate	2018-10-17
AnnouncementXML	Submission_2023-08-28_00:11:26.198.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Huanxin Chen
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	iTRAQ8plex reporter+balance reagent acylated residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2018-10-16 23:46:05	ID requested
1	2018-10-16 23:55:33	announced
⏵ 2	2023-08-28 00:11:27	announced	2023-08-28: Update information.

Li XY, Hou HT, Chen HX, Liu XC, Wang J, Yang Q, He GW, Preoperative plasma biomarkers associated with atrial fibrillation after coronary artery bypass surgery. J Thorac Cardiovasc Surg, 162(3):851-863.e3(2021) [pubmed]

submitter keyword: postoperative atrial fibrillation, sinus rhythm, proteomic

Guowei He
contact affiliation	Teda International Cardiovascular Hospital
contact email	gwhezj@163.com
lab head
Huanxin Chen
contact affiliation	Teda International Cardiovascular Hospital
contact email	huanxincon@163.com
dataset submitter

iProX dataset URI