PXD011373

PXD011373 is an original dataset announced via ProteomeXchange.

Title	The effect of aqueous extract Gynura procumbens on fertility of diabetes induced male rats using proteomic approach
Description	Medicinal plants or herbs have been long used in traditional practice and considered as an alternative treatment for diseases. Gynura procumbens is one of the herbs that showed high potential for treating various diseases such as diabetes mellitus, cancer and fertility. Previous study demonstrated G. procumbens potential as anti-hyperglycaemic agent by lowering the blood glucose level of diabetic-induced male rats (Hassan et al. 2010). G. procumbens is claimed to emulate the mechanism of action in insulin, by increasing the glucose intake in the skeletal muscle (Hassan et al. 2010). Another study made by Kamaruzaman & Mat Noor (2017) showed that G. procumbens extract has the ability to improve fertility of diabetes-induced male rats. Diabetes mellitus has caused deleterious effect on male reproductive system due to disruption in spermatogenesis, testicular impairment as well as erectile and ejaculation dysfunction (Alves et al. 2013). Testicular impairment in diabetic rats leads to low sperm quality. Hence, proteomic analysis was performed to identify the differential expressions of total sperm protein after treatment of G. procumbens extract.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:49:55.861.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wan Aizat
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2018-10-16 06:29:30	ID requested
1	2019-05-20 00:20:12	announced
⏵ 2	2024-10-22 04:49:58	announced	2024-10-22: Updated project metadata.

10.1155/2018/9201539;

Kamaruzaman KA, Aizat WM, Mat Noor M, Improved Fertility of Diabetic Rats: Preliminary Study of Sperm Proteomic. Evid Based Complement Alternat Med, 2018():9201539(2018) [pubmed]

submitter keyword: fertility,Gynura procumbens, proteomic, diabetes mellitus

Dr. Wan Mohd Aizat
contact affiliation	Institute of Systems Biology (INBIOSIS), Universiti Kebangsaan Malaysia (UKM), 43600 UKM, Bangi, Selangor, Malaysia
contact email	wma@ukm.edu.my
lab head
Wan Aizat
contact affiliation	Institute of Systems Biology (INBIOSIS), Universiti Kebangsaan Malaysia (UKM), Bangi, Selangor, Malaysia
contact email	wma@ukm.edu.my
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/05/PXD011373

PRIDE project URI

• PRIDE
  1. PXD011373
     1. Label: PRIDE project
     2. Name: The effect of aqueous extract Gynura procumbens on fertility of diabetes induced male rats using proteomic approach