PXD011347

PXD011347 is an original dataset announced via ProteomeXchange.

Title	LC-MS/MS analyses of human PDAC cell lines after treatment with a new SUMO inhibitor
Description	Pancreatic ductal adenocarcinoma (PDAC) still carries a dismal prognosis with overall five-year survival of 8%. Conventional combination chemotherapies are a clear advance in the treatment of PDAC, however subtypes of the disease exist, which exhibit extensive resistance to such therapies. Genomic MYC amplifications represent a distinct subset of PDAC with an aggressive tumor biology. It is clear that hyperactivation of MYC generates dependencies that can be exploited therapeutically. To find MYC-associated dependencies we analyzed human PDAC expression datasets. We observed that MYC is connected to the SUMOylation machinery in PDAC. Components of the SUMO pathway mark a PDAC subtype with worse prognosis and we provide evidence that hyperactivation of MYC is connected to an increased sensitivity to a novel SUMO inhibitor with a potential for further clinical development.
HostingRepository	PRIDE
AnnounceDate	2020-01-06
AnnouncementXML	Submission_2020-01-06_01:19:02.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kathrin Kunz
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2018-10-12 03:30:48	ID requested
⏵ 1	2020-01-06 01:19:03	announced

Dataset with its publication pending

curator keyword: Biomedical

submitter keyword: Pancreatic cancer, SUMO, MYC, LC-MS/MS

Prof. Dr. Ulrich Keller
contact affiliation	III. Medical Clinic Technical University Munich Ismaninger Stra??????e 22 81675 Munich Germany
contact email	ulrich.keller@tum.de
lab head
Kathrin Kunz
contact affiliation	Institute of Biochemistry II, Goethe University, Frankfurt am Main
contact email	K.Kunz@med.uni-frankfurt.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/01/PXD011347

PRIDE project URI

• PRIDE
  1. PXD011347
     1. Label: PRIDE project
     2. Name: LC-MS/MS analyses of human PDAC cell lines after treatment with a new SUMO inhibitor