PXD011340

PXD011340 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	The mRNA-bound proteome of Leishmania mexicana is stage-regulated with distinct transcript target pools
Description	Leishmania species parasite infections, termed the leishmaniases, cause significant global infectious disease burden. The lifecycle of the parasite embodies three main stages that require precise coordination of gene regulation to survive drastic environmental shifts transitioning from sandfly to mammalian hosts. Constitutive transcription in these kinetoplastid parasites is overwhelmingly reliant on post-transcriptional mechanisms, yet strikingly few Leishmania trans-regulator proteins are known. Utilizing optimised crosslinking and in-depth, quantified mass spectrometry, we present a comprehensive analysis of over 1,400 mRNA binding proteins (mRBPs) and whole cell proteomes from the three main lifecycle stages.
HostingRepository	MassIVE
AnnounceDate	2019-04-08
AnnouncementXML	Submission_2019-04-08_09:37:07.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Adam Dowle
SpeciesList	scientific name: Leishmania mexicana; NCBI TaxID: 5665;
ModificationList	Carbamidomethyl; Oxidation
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2018-10-11 01:41:14	ID requested
⏵ 1	2019-04-08 09:37:09	announced

Publication List

de Pablos LM, Ferreira TR, Dowle AA, Forrester S, Parry E, Newling K, Walrad PB, : Novel Genetic Insight into an Ancient Parasite. Mol Cell Proteomics, 18(7):1271-1284(2019) [pubmed]

de Pablos LM, Ferreira TR, Dowle AA, Forrester S, Parry E, Newling K, Walrad PB, : Novel Genetic Insight into an Ancient Parasite. Mol Cell Proteomics, 18(7):1271-1284(2019) [pubmed]

Keyword List

submitter keyword: mRNA-bound proteome, mRNA binding proteins, mRBPs, mRBPome, parasite lifecycle

submitter keyword: mRNA-bound proteome, mRNA binding proteins, mRBPs, mRBPome, parasite lifecycle

Contact List

Dr. Pegine Walrad
contact affiliation	University of York
contact email	pegine.walrad@york.ac.uk
lab head
Adam Dowle
contact affiliation	University of York
contact email	adam.dowle@york.ac.uk
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000083023