PXD011340
PXD011340 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | The mRNA-bound proteome of Leishmania mexicana is stage-regulated with distinct transcript target pools |
Description | Leishmania species parasite infections, termed the leishmaniases, cause significant global infectious disease burden. The lifecycle of the parasite embodies three main stages that require precise coordination of gene regulation to survive drastic environmental shifts transitioning from sandfly to mammalian hosts. Constitutive transcription in these kinetoplastid parasites is overwhelmingly reliant on post-transcriptional mechanisms, yet strikingly few Leishmania trans-regulator proteins are known. Utilizing optimised crosslinking and in-depth, quantified mass spectrometry, we present a comprehensive analysis of over 1,400 mRNA binding proteins (mRBPs) and whole cell proteomes from the three main lifecycle stages. |
HostingRepository | MassIVE |
AnnounceDate | 2019-04-08 |
AnnouncementXML | Submission_2019-04-08_09:37:07.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Adam Dowle |
SpeciesList | scientific name: Leishmania mexicana; NCBI TaxID: 5665; |
ModificationList | Carbamidomethyl; Oxidation |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2018-10-11 01:41:14 | ID requested | |
⏵ 1 | 2019-04-08 09:37:09 | announced |
Publication List
de Pablos LM, Ferreira TR, Dowle AA, Forrester S, Parry E, Newling K, Walrad PB, : Novel Genetic Insight into an Ancient Parasite. Mol Cell Proteomics, 18(7):1271-1284(2019) [pubmed] |
Keyword List
submitter keyword: mRNA-bound proteome, mRNA binding proteins, mRBPs, mRBPome, parasite lifecycle |
Contact List
Dr. Pegine Walrad | |
---|---|
contact affiliation | University of York |
contact email | pegine.walrad@york.ac.uk |
lab head | |
Adam Dowle | |
contact affiliation | University of York |
contact email | adam.dowle@york.ac.uk |
dataset submitter |
Full Dataset Link List
MassIVE dataset URI |
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000083023 |