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PXD011340

PXD011340 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe mRNA-bound proteome of Leishmania mexicana is stage-regulated with distinct transcript target pools
DescriptionLeishmania species parasite infections, termed the leishmaniases, cause significant global infectious disease burden. The lifecycle of the parasite embodies three main stages that require precise coordination of gene regulation to survive drastic environmental shifts transitioning from sandfly to mammalian hosts. Constitutive transcription in these kinetoplastid parasites is overwhelmingly reliant on post-transcriptional mechanisms, yet strikingly few Leishmania trans-regulator proteins are known. Utilizing optimised crosslinking and in-depth, quantified mass spectrometry, we present a comprehensive analysis of over 1,400 mRNA binding proteins (mRBPs) and whole cell proteomes from the three main lifecycle stages.
HostingRepositoryMassIVE
AnnounceDate2019-04-08
AnnouncementXMLSubmission_2019-04-08_09:37:07.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterAdam Dowle
SpeciesList scientific name: Leishmania mexicana; NCBI TaxID: 5665;
ModificationListCarbamidomethyl; Oxidation
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-10-11 01:41:14ID requested
12019-04-08 09:37:09announced
Publication List
de Pablos LM, Ferreira TR, Dowle AA, Forrester S, Parry E, Newling K, Walrad PB, : Novel Genetic Insight into an Ancient Parasite. Mol Cell Proteomics, 18(7):1271-1284(2019) [pubmed]
Keyword List
submitter keyword: mRNA-bound proteome, mRNA binding proteins, mRBPs, mRBPome, parasite lifecycle
Contact List
Dr. Pegine Walrad
contact affiliationUniversity of York
contact emailpegine.walrad@york.ac.uk
lab head
Adam Dowle
contact affiliationUniversity of York
contact emailadam.dowle@york.ac.uk
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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