PXD011321

PXD011321 is an original dataset announced via ProteomeXchange.

Title	The dynamic proteome of Influenza A virus infection
Description	We combined metabolic pulse labeling and quantitative shotgun proteomics to globally monitor protein synthesis upon infection of human cells with a human- and a bird-adapted IAV strain. While production of host proteins was remarkably similar, we observed striking differences in the kinetics of viral protein synthesis over the course of infection. Most importantly, the matrix protein M1 was inefficiently produced by the bird-adapted strain at later stages.
HostingRepository	PRIDE
AnnounceDate	2019-11-11
AnnouncementXML	Submission_2020-01-13_05:25:06.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Boris Bogdanow
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; acetylated residue; deamidated residue
Instrument	LTQ Orbitrap Velos; Q Exactive; Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2018-10-09 23:35:59	ID requested
1	2019-11-11 06:58:52	announced
⏵ 2	2020-01-13 05:25:07	announced	2020-01-13: Updated publication reference for PubMed record(s): 31797923.

Bogdanow B, Wang X, Eichelbaum K, Sadewasser A, Husic I, Paki K, Budt M, Hergeselle M, Vetter B, Hou J, Chen W, Wiebusch L, Meyer IM, Wolff T, Selbach M, The dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant. Nat Commun, 10(1):5518(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: A549, avian flu, human flu, Influenza, AHA, SILAC, protein de novo synthesis

Matthias Selbach
contact affiliation	Proteome Dynamics, Max-Delbrück-Center for Molecular Medicine
contact email	Matthias.Selbach@mdc-berlin.de
lab head
Boris Bogdanow
contact affiliation	MDC Berlin
contact email	boris.bogdanow@mdc-berlin.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/11/PXD011321

PRIDE project URI

• PRIDE
  1. PXD011321
     1. Label: PRIDE project
     2. Name: The dynamic proteome of Influenza A virus infection